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Design, methodology, and preliminary results of the non-human primates eye study
PurposeTo describe the normative profile of ophthalmic parameters in a healthy cynomolgus monkey colony, and to identify the characteristic of the...
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Immunogenicity and efficacy of VLA2001 vaccine against SARS-CoV-2 infection in male cynomolgus macaques
BackgroundThe fight against COVID-19 requires mass vaccination strategies, and vaccines inducing durable cross-protective responses are still needed....
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Safety of terminally gamma-ray-sterilized screws coated with fibroblast growth factor 2-calcium phosphate composite layers in non-human primates
Screws coated with fibroblast growth factor 2 (FGF-2)-calcium phosphate (CP) composite layers exhibit enhanced soft tissue and bone formation and...
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PET imaging of an optimized anti-PD-L1 probe 68Ga-NODAGA-BMS986192 in immunocompetent mice and non-human primates
BackgroundAdnectin is a protein family derived from the 10th type III domain of human fibronectin ( 10 Fn3) with high-affinity targeting capabilities....
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Total-body imaging of mu-opioid receptors with [11C]carfentanil in non-human primates
PurposeMu-opioid receptors (MORs) are widely expressed in the central nervous system (CNS), peripheral organs, and immune system. This study measured...
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Microbiome Studies in Non-human Primates
Purpose of ReviewObservations of differing bacterial, intestinal microbiomes in people living with HIV have propelled interest in contributions of...
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Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates
BackgroundMonoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven...
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Cervical catheter placement leads to improved rostral distribution of a radiolabeled 18F-baclofen analog in cynomolgus monkeys
BackgroundIntrathecal (IT) catheter delivery of baclofen via continuous infusion using an implantable pump is an important means of treating patients...
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PET imaging of kappa opioid receptors and receptor expression quantified in neuron-derived extracellular vesicles in socially housed female and male cynomolgus macaques
Recent positron emission tomography (PET) studies of kappa opioid receptors (KOR) in humans reported significant relationships between KOR...
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Traditional Chinese Medicine Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration
BackgroundAs a supplement for promoting hair health, Shi-Bi-Man (SBM) is a prescription comprising various traditional Chinese medicines. Though SBM...
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Biogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior
Most previous studies in the pathophysiology of major depressive disorder (MDD) focused on fecal samples, which limit the identification of the gut...
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Multifocal electroretinography increases following experimental glaucoma in nonhuman primates with retinal ganglion cell axotomy
PurposeTo determine whether short-latency changes in multifocal electroretinography (mfERG) observed in experimental glaucoma (EG) are secondary...
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Preclinical development of ZED8, an 89Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy
BackgroundZED8 is a novel monovalent antibody labeled with zirconium-89 for the molecular imaging of CD8. This work describes nonclinical studies...
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Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys
Adolescent depression is a common and serious mental disorder with unique characteristics that are distinct from adult depression. The adult...
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The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain
BackgroundPositron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [ 18 F]UC...
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XFab-α4-1BB/CD40L fusion protein activates dendritic cells, improves expansion of antigen-specific T cells, and exhibits antitumour efficacy in multiple solid tumour models
BackgroundAdditional immunotherapies are still warranted for non-responders to checkpoint inhibitors with refractory or relapsing cancers, especially...
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PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys
PurposeProgrammed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade...
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Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver
Non-human primates (NHPs) represent the most valuable animals for drug discovery. However, the current main challenge remains that the NHP has not...
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Gene Editing for the Treatment of Hypercholesterolemia
Purpose of ReviewHere, we summarize the key findings from preclinical studies that tested the concept that editing of hepatic genes can lower plasma...
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Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
Despite the substantial progress made in identifying genetic defects in autism spectrum disorder (ASD), the etiology for majority of ASD individuals...
