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Perspective on Emerging Therapies to Achieve Functional Cure of Chronic Hepatitis B
Purpose of ReviewAdvancements in our understanding of the hepatitis B viral (HBV) life cycle have paved the way for novel approaches to treat HBV...
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Estimating the cure proportion of stage IA lung adenocarcinoma: a population-based study
BackgroundWe aimed to investigate the factors influencing the cure, recurrence, and metastasis rates of stage IA lung adenocarcinoma, using a mixed...
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A nomogram based on clinical multivariate factors predicts delayed cure after microvascular decompression for hemifacial spasm
BackgroundThe course of disease after microvascular decompression (MVD) in patients with hemifacial spasm (HFS) is variable. The purpose of this...
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More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure
Purpose of ReviewAn HIV cure that eliminates the viral reservoir or provides viral control without antiretroviral therapy (ART) is an urgent need in...
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The Importance of Social Engagement in the Development of an HIV Cure: A Systematic Review of Stakeholder Perspectives
As research into the development of an HIV cure gains prominence, assessing the perspectives of stakeholders becomes imperative. It empowers...
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Antibiotics efficacy in clinical and microbiological cure of uncomplicated urinary tract infection: a systematic review and network meta-analysis
PurposeFosfomycin has been used more frequently in managing uncomplicated urinary tract infections (UTIs) due to decreased compliance and increased...
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Functional cure is associated with younger age in children undergoing antiviral treatment for active chronic hepatitis B
Background and AimsFunctional cure is difficult to achieve using current antiviral therapies; moreover, limited data are available regarding...
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Qualitative Evidence on the Implementation of Cure Violence in Trinidad and Tobago
Violence is a significant social problem in many cities throughout the world. In seeking to prevent or control violence, communities have put in...
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The scientific basis of combination therapy for chronic hepatitis B functional cure
Functional cure of chronic hepatitis B (CHB) — or hepatitis B surface antigen (HBsAg) loss after 24 weeks off therapy — is now the goal of treatment,...
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The estimation of long and short term survival time and associated factors of HIV patients using mixture cure rate models
BackgroundHIV is one of the deadliest epidemics and one of the most critical global public health issues. Some are susceptible to die among people...
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(Neo)adjuvant approaches in lung cancer—paving the road to a cure
Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of metastatic non-small-cell lung cancer (NSCLC). During the past few...
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Impaired health-related quality of life in the HCV cure era: who is concerned? (ANRS CO22 HEPATHER French cohort)
PurposeHepatitis C virus (HCV) cure after treatment with direct-acting antivirals (DAAs) can improve health-related quality of life (HRQoL). However,...
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Incidence, functional outcomes and cure rate of hematogenous infection in a 2,498 Total Knee Arthroplasties cohort
PurposeThe primary aim of the present study is to report the late acute hematogenous (LAH) prosthetic joint infection (PJI) cure rate following Total...
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A new cure model that corrects for increased risk of non-cancer death: analysis of reliability and robustness, and application to real-life data
BackgroundNon-cancer mortality in cancer patients may be higher than overall mortality in the general population due to a combination of factors,...
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Nidus Compacity Determined by Semi-Automated Segmentation is a Strong Quantitative Predictor of Brain Arterio-Venous Malformation Cure
Background and ObjectiveA compact nidus is a well-known feature of good outcome after treatment in brain arteriovenous malformations (bAVM). This...
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Predictive models for functional cure in patients with CHB receiving PEG-IFN therapy based on HBsAg quantification through meta-analysis
Background and aimsThe efficacy of achieving HBsAg clearance through pegylated interferon (PEG-IFNα) therapy in patients with chronic hepatitis B...
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Exploring the Impact of Airway Microbiome on Asthma Morbidity: A Focus on the “Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma—CURE” Project
The asthma pandemic imposes a huge burden on patients and health systems in both developed and develo** countries. Despite available treatments,...
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Why the Vonoprazan Helicobacter pylori Therapies in the US-European Trial Produced Unacceptable Cure Rates
IntroductionHelicobacter pylori infects a large percentage of the world’s population and is etiologically related to gastric cancer. The U.S. Food...
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Novel Combination Strategies With Investigational Agents for Functional Cure of Chronic Hepatitis B Infection
Purpose of ReviewFunctional cure, defined as sustained seroclearance of hepatitis B surface antigen (HBsAg), is a favorable treatment endpoint in...
