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Effectiveness of [67Cu]Cu-trastuzumab as a theranostic against HER2-positive breast cancer
PurposeTo evaluate the imaging and therapeutic properties (theranostic) of 67 Cu-labeled anti-human epidermal growth factor receptor II (HER2)...
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An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [64/67Cu]Cu-SARTATE
In a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [ 64 / 67 Cu]Cu-SARTAT...
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Detection and therapy of neuroblastoma minimal residual disease using [64/67Cu]Cu-SARTATE in a preclinical model of hepatic metastases
BackgroundA major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal...
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In vitro and in vivo characterization of [64Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors
PurposeHypoxic tumors are associated with therapy resistance and poor cancer prognosis, but methods to detect and counter tumor hypoxia remain...
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Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications
BackgroundExpanding therapeutic possibilities have improved disease-related prospects for breast cancer patients. Pathological analysis on a tumor...
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Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry
BackgroundSPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited...
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Chelator boosted tumor-retention and pharmacokinetic properties: development of 64Cu labeled radiopharmaceuticals targeting neurotensin receptor
PurposeAccumulating evidence suggests that neurotensin (NTS) and neurotensin receptors (NTSRs) play key roles in lung cancer progression by...
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Production of the PET radionuclide 61Cu via the 62Ni(p,2n)61Cu nuclear reaction
BackgroundThere are only a handful of true theranostic matched pairs, and in particular the theranostic radiocopper trio 61 Cu, 64 Cu and 67 Cu, for...
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New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms
Neuroendocrine neoplasms (NEN) are a heterogeneous group of tumours derived from cells of neuroendocrine origin and can potentially arise everywhere...
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Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms
BackgroundTumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environment, associated with malignant progression,...
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Triple modality image reconstruction of PET data using SPECT, PET, CT information increases lesion uptake in images of patients treated with radioembolization with \(^{90}Y\) micro-spheres
PurposeNuclear medicine imaging modalities like computed tomography (CT), single photon emission CT (SPECT) and positron emission tomography (PET)...
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Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?
BackgroundIn order to support the ongoing research across Europe to facilitate access to novel radionuclides, the PRISMAP consortium (European...
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Radionuclide imaging and therapy directed towards the tumor microenvironment: a multi-cancer approach for personalized medicine
Targeted radionuclide theranostics is becoming more and more prominent in clinical oncology. Currently, most nuclear medicine compounds researched...
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Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression and [64Cu]Cu-DOTA-AE105 uPAR-PET/CT in Patient-Derived Xenograft Models of Oral Squamous Cell Carcinoma
Purpose[ 64 Cu]Cu-DOTA-AE105 urokinase-type plasminogen activator receptor (uPAR)-PET/CT is a novel and promising imaging modality for cancer...
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Trans-cyclooctene—a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs
BackgroundTrans -cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand...
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Joint EANM/EANO/RANO/SNMMI practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor ligands: version 1.0
PurposeTo provide practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin...
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Theranostics in neuroendocrine tumors: an overview of current approaches and future challenges
Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is...
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New Drug Delivery Systems Developed for Brain Targeting
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (B CSF ) are two of the most complex and sophisticated concierges that defend...
