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Emergency critical care: closing the gap between onset of critical illness and intensive care unit admission
Critical illness is an exquisitely time-sensitive condition and follows a disease continuum, which always starts before admission to the intensive...
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Do critical illness survivors with multimorbidity need a different model of care?
There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous research has largely...
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Systemic inflammation and delirium during critical illness
PurposeThe purpose of this study was to determine associations between markers of inflammation and endogenous anticoagulant activity with delirium...
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Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets
Critical illness is characterized by a hypercatabolic response encompassing endocrine and metabolic alterations. Not only the uptake, synthesis and...
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Understanding the pathophysiology of acute critical illness: translational lessons from zebrafish models
The models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish ( Danio...
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Pharmacokinetic Alterations Associated with Critical Illness
Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect drug pharmacokinetics and pharmacodynamics making dose...
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Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes
BackgroundSevere weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific insights and...
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Dysphagia Rehabilitation in Dysphagic Patients with Acute or Critical Illness: A Systematic Review and Meta-Analysis
Dysphagia or swallowing dysfunction is common in patients with acute or critical illness, and diverse methods of dysphagia rehabilitation are...
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The burden of critical illness among adults in a Swedish region—a population-based point-prevalence study
BackgroundPatients with critical illness have a high risk of mortality. Key decision-making in the health system affecting the outcomes of critically...
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Biological basis of critical illness subclasses: from the bedside to the bench and back again
Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute kidney injury (AKI) are associated with high in-hospital...
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Vitamin K: a potential missing link in critical illness–a sco** review
BackgroundVitamin K is essential for numerous physiological processes, including coagulation, bone metabolism, tissue calcification, and antioxidant...
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Financial outcomes after pediatric critical illness among commercially insured families
Critical illness results in subjective financial distress for families, but little is known about objective caregiver finances after a child’s...
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Critical illness at the emergency department of a Tanzanian national hospital in a three-year period 2019–2021
BackgroundCritically ill patients have life-threatening conditions requiring immediate vital organ function intervention. But, critical illness in...
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Critical illness-related corticosteroid insufficiency (CIRCI) in paediatric patients: a diagnostic and therapeutic challenge
Critical illness-related corticosteroid insufficiency or CIRCI is characterized by acute and life-threatening disfunction of...
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Association between cholinesterase activity and critical illness brain dysfunction
BackgroundDelirium is a frequent manifestation of acute brain dysfunction and is associated with cognitive impairment. The hypothesized mechanism of...
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Psychometric properties of health-related quality of life instruments used in survivors of critical illness: a systematic review
Background and objectivesHealth-related quality of life (HRQoL) is a patient-reported measure of health status. However, research on the psychometric...
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Critical illness among patients experiencing homelessness: a retrospective cohort study
PurposeTo understand the epidemiology and healthcare use of critically ill patients experiencing homelessness compared to critically ill patients...
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Clinical Outcomes and Determinants of Survival in Patients with Hematologic Malignancies Admitted to Intensive Care Units with Critical Illness
Outcomes of patients with hematologic malignancies requiring ICU care for critical illness are suboptimal and represent a major unmet need in this...
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Sleep in Critical Illness Physiology, Assessment, and Its Importance to ICU Care
For decades heavily sedated ICU patients were assumed to be asleep. However, in the past 20 years, physiologic and epidemiologic studies have...
