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Synthesizing Core Outcome Sets for outcomes research in cohort studies: a systematic review
BackgroundLife course studies are designed to “collect once, use multiple times” for observational and, increasingly, interventional research. Core...
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Identifying common core outcome domains from core outcome sets of musculoskeletal conditions: protocol for a systematic review
BackgroundCore outcome sets (COSs) aim to reduce outcome heterogeneity in clinical practice and research by suggesting a minimum number of...
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How to reach agreement: the impact of different analytical approaches to Delphi process results in core outcomes set development
BackgroundCore outcomes sets are increasingly used to define research outcomes that are most important for a condition. Different consensus methods...
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The Importance of Grey and Qualitative Literature in Develo** Domestic Violence and Abuse and Child Maltreatment Core Outcome Sets: A Brief Report
PurposeCore Outcome Sets (COS) are agreed sets of outcomes to be used in all trials that evaluate the effect of interventions. This report considers...
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A protocol for develo** core outcome sets for laparoscopic hiatal hernia repair
BackgroundHiatal hernias negatively damage patients’ health and life quality. Laparoscopic hiatal hernia repair is currently the gold standard for...
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A Foundation for Patient-Centered Core Impact Sets: Key Learnings from Past and Existing Approaches
Despite growing commitment to patient centricity, challenges persist in consistently identifying the impacts of disease and/or treatment that...
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The CORE-KDT study: a mixed methods protocol to establish core outcomes for refractory childhood epilepsy treated with ketogenic diet therapy
BackgroundA core outcome set defines the minimum outcomes that should be included in clinical trials, audit or practice. The aim being to increase...
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Development of core outcome sets of Food for Special Medical Purposes designed for type 2 diabetes mellitus: a study protocol
BackgroundThe Chinese government stipulates all food for special medical purposes (FSMP) designed for specific diseases to be tested in clinical...
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Core outcomes for speech-language services in Ontario schools: a group concept map** study and guiding framework
BackgroundEstablishing the most important outcomes for school-based speech-language therapy is essential to guide future research and program...
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Patient-Centered Core Impact Sets: What They are and Why We Need Them
A quote attributed to Mark Twain states, “What gets us into trouble is not what we don’t know. It’s what we know for sure that just ain’t so.” The...
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Core outcome sets in clinical laser research: how better evidence can be better for patients
Core outcome sets, or the minimum sets of outcomes that would be used in all clinical studies of a given disease or condition, have the potential to...
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Validation of patient- and GP-reported core sets of quality indicators for older adults with multimorbidity in primary care: results of the cross-sectional observational MULTIqual validation study
BackgroundOlder adults with multimorbidity represent a growing segment of the population. Metrics to assess quality, safety and effectiveness of care...
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coreSCD: multi-stakeholder consensus on core outcomes for sickle cell disease clinical trials
BackgroundWith the dramatic increase in the pipeline for new sickle cell disease (SCD) therapies in recent years, the time is ripe to ensure a robust...
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A survey of knowledge, perceptions and use of core outcome sets among clinical trialists
BackgroundCore outcome sets (COS) are standardised sets of outcomes, which represent the minimum outcomes that should be measured and reported in...
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Core Outcome Sets (COS) related to pregnancy and childbirth: a systematic review
BackgroundSystematic reviews often conclude low confidence in the results due to heterogeneity in the reported outcomes. A Core Outcome Set (COS) is...
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An international Delphi consensus process to determine a common data element and core outcome set for frailty: FOCUS (The Frailty Outcomes Consensus Project)
BackgroundDespite increased recognition of frailty and its importance, high quality evidence to guide decision-making is lacking. There has been...
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Outcome reporting in randomized controlled trials (RCTs) on the pharmacological management of idiopathic overactive bladder (OAB) in women; a systematic review for the development of core outcome sets (COS)
Introduction and hypothesisEvidence on OAB management remains suboptimal and methodological limitations in randomized control trials (RCTs) affect...