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Further considerations for placebo controls in surgical trials
The use of invasive placebo controls in surgical trials can be challenging. The ASPIRE guidance, published in the Lancet in 2020, provided advice for...
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Myocardial work across different etiologies of right ventricular dysfunction and healthy controls
Evaluating right ventricular (RV) function remains a challenge. Recently, novel echocardiographic assessment of RV myocardial work (RVMW) by...
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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and...
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Task-state skin potential abnormalities can distinguish major depressive disorder and bipolar depression from healthy controls
Early detection of bipolar depression (BPD) and major depressive disorder (MDD) has been challenging due to the lack of reliable and easily...
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Characterisation of the bacterial microbiome in patients with rosacea and healthy controls
BackgroundRosacea is a chronic inflammatory skin disorder that significantly impairs quality of life, however, its pathophysiology is still unclear....
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MiR-9-1 controls osteoblastic regulation of lymphopoiesis
The highly conserved MicroRNA-9 (miR-9) family consists of three members. We discovered that miR-9-1 deletion reduced mature miR-9 expression,...
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On the use of non-concurrent controls in platform trials: a sco** review
BackgroundPlatform trials gained popularity during the last few years as they increase flexibility compared to multi-arm trials by allowing new...
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Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data
BackgroundComorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously...
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Changes in foveal avascular zone parameters in individuals with prediabetes compared to normoglycemic controls: a systematic review and meta-analysis
To investigate changes in foveal avascular zone parameters in individuals with prediabetes compared to normoglycemic controls. PUBMED, Scopus and...
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Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls
BackgroundLiquid biopsies have become an integral part of cancer management as minimally invasive options to detect molecular and genetic changes....
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Comparative analysis of tear cytokines in patients with glaucoma, ocular hypertension, and healthy controls
PurposeTo investigate the ocular surface inflammation in patients with primary open angle glaucoma and ocular hypertension by analyzing tears and to...
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Self-Report Measures of Sensory Phenomena in Body-Focused Repetitive Behaviors: A Comparison to Healthy Controls
BackgroundEarly studies identified sensory phenomena as an important facet of hair pulling and skin picking. Research in this area has grown in...
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Do pseudoxanthoma elasticum patients have higher prevalence of kidney stones on computed tomography compared to hospital controls?
BackgroundPseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by diminished inorganic plasma pyrophosphate (PPi), a strong...
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Macroscale EEG characteristics in antipsychotic-naïve patients with first-episode psychosis and healthy controls
Electroencephalography in patients with a first episode of psychosis (FEP) may contribute to the diagnosis and treatment response prediction....
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Comparison of kinematics and pedobarography findings between the unaffected foot of patients with unilateral clubfoot and controls
PurposeIdiopathic clubfoot (ICF) involves structural abnormalities in the lower extremities. Approximately half of patients have unilateral ICF,...
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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls
BackgroundVarious conservative and surgical approaches exist to treat Robin sequence (RS), but their effects on facial profile and mandibular...
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Peripheral artery disease in patients with schizophrenia as compared to controls
BackgroundPatients with schizophrenia have an increased prevalence of risk factors for peripheral artery disease (PAD) and is expected to have an...
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A comparative study to evaluate abdominal wall dynamics in patients with incisional hernia compared to healthy controls
BackgroundIncisional hernia is a common complication following abdominal surgery. It causes change in function of core abdominal muscles leading to...
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Sexual health in long-term breast cancer survivors: a comparison with female population controls from the HUNT study
PurposeSexual health is an important aspect of quality of life. Knowledge concerning sexual health in long-term breast cancer survivors (BCSs) is...
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