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Mixed hypogonadism: a neglected combined form of hypogonadism
PurposeKallmann syndrome is a rare disease characterized by delayed puberty, infertility and anosmia. We report the clinical and genetic...
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Successful pregnancy and delivery after ovulation induction therapy in a woman with congenital hypogonadotropic hypogonadism: a case report
BackgroundCongenital hypogonadotropic hypogonadism (CHH) is a rare disorder resulting from a deficient secretion of the episodic...
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Idiopathic hypogonadotropic hypogonadism caused by compound heterozygosity for two novel mutations in the GNRH1 gene: a case report
BackgroundIdiopathic hypogonadotropic hypogonadism (IHH) is a rare congenital or acquired genetic disorder caused by gonadotropin-releasing hormone...
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Regional genotypic variations in normosmic congenital hypogonadotropic hypogonadism: our experience and systematic review
PurposeTo describe phenotype-genotype data of Asian-Indian normosmic congenital hypogonadotropic hypogonadism (nCHH) from our centre and perform a...
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Clinical, hormonal, and genetic characteristics of 25 Chinese patients with idiopathic hypogonadotropic hypogonadism
BackgroundIdiopathic hypogonadotropic hypogonadism (IHH) is a type of congenital disease caused by a variety of gene variants leading to dysfunction...
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Adrenal Hypoplasia Congenita—Hypogonadotropic Hypogonadism Syndrome Due to NR0B1 Gene Mutations
Adrenal hypoplasia congenita (AHC) is a rare disorder of the adrenal gland due to mutations in the nuclear receptor superfamily 0, group B, member 1 (
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GNRHR-related central hypogonadism with spontaneous recovery – case report
BackgroundCongenital hypogonadotropic hypogonadism (CHH) is a clinically and genetically heterogeneous disease characterized by absent or incomplete...
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Diagnosis and treatment of hypogonadism in men seeking to preserve fertility – what are the options?
Male hypogonadism is a clinical syndrome that results in low testosterone levels and frequently leads to infertility. The syndrome occurs due to...
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Bibliometrics and visualization analysis of literature on male hypogonadism from 2000 to 2023: research focus and frontiers
Male hypogonadism can seriously affect male health and fertility, yet comprehensive bibliometric and visualization analyses of research in this area...
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Serum inhibin B for differentiating between congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty: a systematic review and meta-analysis
PurposeThe distinction between congenital hypogonadotropic hypogonadism (CHH) and constitutional delay of growth and puberty (CDGP) in patients with...
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Prior testosterone replacement therapy may impact spermatogenic response to combined gonadotropin therapy in severe congenital hypogonadotropic hypogonadism
ObjectiveTo study the effect of prior testosterone replacement therapy (TRT) on the spermatogenic response to combined gonadotropin therapy (CGT) in...
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Predictors of reproductive and non-reproductive outcomes of gonadotropin mediated pubertal induction in male patients with congenital hypogonadotropic hypogonadism (CHH)
PurposeTo investigate predictors of testicular response and non-reproductive outcomes (height, body proportions) after gonadotropin-induced puberty...
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Serum insulin-like factor 3 quantification by LC–MS/MS in male patients with hypogonadotropic hypogonadism and Klinefelter syndrome
PurposeInsulin-like factor 3 (INSL3) is an emerging testicular marker, yet larger studies elucidating the clinical role of INSL3 in patients with...
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Cardiometabolic indices predict hypogonadism in male patients with type 2 diabetes
PurposeTo evaluate in men with type 2 diabetes the association of cardiometabolic indices [Visceral Adiposity Index (VAI), Triglyceride Glucose Index...
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The role of male hypogonadism, aging, and chronic diseases in characterizing adult and elderly men with erectile dysfunction: a cross-sectional study
BackgroundErectile function depends on a complex interaction between demographic, metabolic, vascular, hormonal, and psychological factors that...
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Age at diagnosis in patients with chronic congenital endocrine conditions: a regional cohort study from a reference center for rare diseases
BackgroundFor chronic congenital endocrine conditions, age at diagnosis is a key issue with implications for optimal management and psychological...
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Reproductive outcomes in women with hypogonadotrophic hypogonadism, a case series study
BackgroundHypogonadotropic hypogonadism (HH) is a rare condition in which there is gonadal hypofunction due to absence of gonadotropin drive. In this...
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Reproductive outcomes of microdissection testicular sperm extraction in hypogonadotropic hypogonadal azoospermic men after gonadotropin therapy
PurposeMale infertility caused by hypogonadotropic hypogonadism (HH) is not common. The main treatment is gonadotropins for 12 months or longer. If...
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Secondary hypogonadism following hand, foot, and mouth disease in an adult: a case report and review of literature
BackgroundPrevious reports have described hypogonadism associated with virus infection such as hantavirus, human immunodeficiency virus (HIV) or...
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Fertility issues in hypopituitarism
Women with hypopituitarism have lower fertility rates and worse pregnancy outcomes than women with normal pituitary function. These disparities exist...