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Revisiting large complex ventral hernia repair: multimodal hybrid technique deploying preoperative Botulinum Toxin A injection, laparoscopic anterior components separation and open mesh repair
In the past, various techniques had been described to repair large complex ventral hernias. Laparoscopic technique of components separation showed...
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Early outcomes of open anterior versus posterior components separation with transversus abdominis release for large median incisional hernias: a retrospective stepwise analysis
BackgroundComplex incisional hernia is still a debatable topic, with increasing incidence and an increased local and systemic postoperative morbidity...
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Phase separation in cGAS-STING signaling
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes....
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Two-meshes approach in posterior component separation with transversus abdominis release: the IMPACT study (Italian Multicentric Posterior-separation Abdominal Complex hernia Transversus-release)
BackgroundSurgical management of large ventral hernias (VH) has remained a challenge. Various techniques like anterior component separation and...
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Nanorobotic artificial blood components and its therapeutic applications: A minireview
Numerous scientific and medical domains have been revolutionized by nanotechnology, opening up unprecedented opportunities for healthcare...
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Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway
RNA binding proteins (RBPs) contributes to cancer progression, but the underlying mechanism reminds unclear. Here, we find that DDX21, a...
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Anterior versus posterior component separation technique for advanced abdominal wall reconstruction: a proposed algorithm
ObjectiveThe precise indications for employing the anterior component separation technique (ACST) and the Transversus Abdominis Release (TAR) in...
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Preliminary study on the separation of specular reflection and backscattering components using synthetic aperture beamforming
PurposeIn the early stages of atherosclerosis, the luminal surface of the arterial wall becomes rough due to injury and detachment of endothelial...
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Liquid–liquid phase separation in tumor biology
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS...
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To Leave is to Die a Little: Assessing the Symptom Structure of Separation Anxiety Disorder in Left-Behind Emerging Adults
The literature on separation anxiety disorder (SAD) presented two contentious issues relating to its assessment. First, studies are scarce in...
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling...
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Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry
BackgroundTanreqing capsules (TRQCs) and Tanreqing injections (TRQIs) are widely used in the treatment of respiratory diseases. In this study, a...
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The causal relationship of human blood metabolites with the components of Sarcopenia: a two-sample Mendelian randomization analysis
BackgroundSarcopenia is a progressive loss of muscle mass and function. Since skeletal muscle plays a critical role in metabolic homeostasis,...
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Association of volatile organic compound exposure with metabolic syndrome and its components: a nationwide cross-sectional study
BackgroundMetabolic syndrome (MetS) is a health issue consisting of multiple metabolic abnormalities. The impact of exposure to volatile organic...
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Phase separation drives tumor pathogenesis and evolution: all roads lead to Rome
Cells coordinate numerous biochemical reactions in space and time, depending on the subdivision of the intracellular space into functional...
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Open Anterior Component Separation for Complex Incisional and Ventral Hernias—When and How? Case Series Analysis
Closing the midline in patients with incisional hernias is the cornerstone for a functional reconstruction with low morbidity, low recurrence rates,...
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Outcomes of posterior component separation with transversus abdominis release for repair of abdominally based breast reconstruction donor site hernias
PurposeAbdominally based autologous breast reconstruction (ABABR) is common after mastectomy, but carries a risk of complex abdominal wall hernias....
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Molecular correlates of male germ cell tumors with overgrowth of components resembling somatic malignancies
A small subset of male germ cell tumors (GCT) demonstrates overgrowth of histologic components that resemble somatic malignancies (e.g., sarcoma,...
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How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?
One of the critical definitions of neurodegenerative diseases is the formation of insoluble intracellular inclusion body. These inclusions are found...
