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Complement dysregulation associated with a genetic variant in factor H-related protein 5 in atypical hemolytic uremic syndrome
BackgroundAtypical hemolytic uremic syndrome (aHUS) can be associated with mutations, deletions, or hybrid genes in factor H-related (FHR) proteins.
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An unusual case of adult-onset still’s disease complicated with anti-complement factor H antibodies associated atypical haemolytic uraemic syndrome
BackgroundAtypical haemolytic uremic syndrome (aHUS) is an uncommon form of thrombotic microangiopathy (TMA). However, it remains difficult to...
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Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation
Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP)....
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Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome
BackgroundCoexisting genetic variants in patients with anti-factor H (FH)-associated atypical hemolytic uremic syndrome (aHUS) have implications for...
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The role of complement factor H in gestational diabetes mellitus and pregnancy
BackgroundComplement factor H (CFH) has been found to be associated with insulin resistance. This study assessed the correlation between CFH and...
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Anti-factor H antibody-positive C3 glomerulonephritis secondary to poststreptococcal acute glomerulonephritis with diabetic nephropathy
Poststreptococcal acute kidney glomerulonephritis (PSAGN) has been seen in adults in recent years, especially in patients with type 2 diabetes...
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Serum fibroblast growth factor-2 levels complement vital biomarkers for diagnosing heart failure
BackgroundEarly diagnosis of atrial fibrillation is important as it is crucial for improving patient outcomes. Fibroblast growth factor-2 (FGF2) may...
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Association of elevated levels of peripheral complement components with cortical thinning and impaired logical memory in drug-naïve patients with first-episode schizophrenia
Schizophrenia has been linked to polymorphism in genes encoding components of the complement system, and hyperactive complement activity has been...
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A novel missense mutation in complement factor I predisposes patients to atypical hemolytic uremic syndrome: a case report
BackgroundAtypical hemolytic uremic syndrome, also called the nondiarrheal form of hemolytic uremic syndrome, is a rare disease characterized by the...
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Canonical and non-canonical roles of complement in atherosclerosis
Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the major contributor to the development and progression of...
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The role of complement in kidney disease
The complement cascade comprises soluble and cell surface proteins and is an important arm of the innate immune system. Once activated, the...
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High level of serum complement 3 is a risk factor for vascular stenosis progression in TA patients receiving tocilizumab: a prospective observational study
BackgroundThe IL-6R antibody tocilizumab has been proven effective in treating Takayasu arteritis (TA). However, some patients show silent vascular...
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Complosome — the intracellular complement system
The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known...
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New insights into the immune functions of podocytes: the role of complement
Podocytes are differentiated epithelial cells which play an essential role to ensure a normal function of the glomerular filtration barrier (GFB). In...
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Complement System Deficiencies in Elite Athletes
BackgroundAlthough regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in...
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Association of central serous chorioretinopathy with single nucleotide polymorphisms in complement factor H gene in Iranian population
ObjectivesTo investigate the association of two different single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene with central...
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The complement cascade in lung injury and disease
BackgroundThe complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major...
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The Relationship between the complement system and subclinical carotid atherosclerosis in patients with rheumatoid arthritis
BackgroundPatients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) events and CV mortality. Subclinical carotid...
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Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk
Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains...
