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Coenzyme Q deficiency may predispose to sudden unexplained death via an increased risk of cardiac arrhythmia
Cardiac arrhythmia is currently considered to be the direct cause of death in a majority of sudden unexplained death (SUD) cases, yet the genetic...
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Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium — positive effects on thyroid hormones, cardiovascular mortality, and quality of life
BackgroundSelenium-dependent deiodinases play a central role in thyroid hormone regulation and metabolism. In many European countries, insufficient...
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Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Succinate accumulates during myocardial ischemia and is rapidly oxidized during reperfusion, leading to reactive oxygen species (ROS) production...
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Compound heterozygous inheritance of two novel COQ2 variants results in familial coenzyme Q deficiency
BackgroundPrimary coenzyme Q10 deficiency is a rare disease that results in diverse and variable clinical manifestations. Nephropathy, myopathy and...
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Association of Coenzyme Q10 with Premature Ovarian Insufficiency
The aim of the study was to analyze the relationship between levels of coenzyme Q10 (CoQ10) and the risk of premature ovarian insufficiency (POI). In...
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Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway
BackgroundThe protective effect of Coenzyme Q10 (CoQ10) on the cardiovascular system has been reported, however, whether it can promote early...
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Effect of Coenzyme Q10 Supplementation on Sarcopenia, Frailty, and Falls: A Sco** Review
Coenzyme Q10 (CoQ10) is well-known for its antioxidant effects and has been highlighted in research related to aging and many age-related conditions....
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Neuroprotective effect of hesperidin and its combination with coenzyme Q10 on an animal model of ketamine-induced psychosis: behavioral changes, mitochondrial dysfunctions, and oxidative stress
BackgroundPsychosis is a complex mental illness divided by positive symptoms, negative symptoms, and cognitive decline. Clinically available...
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Primary coenzyme Q10 nephropathy, a potentially treatable form of steroid-resistant nephrotic syndrome
Steroid-resistant nephrotic syndrome (SRNS) is a genetically heterogeneous kidney disease that is the second most frequent cause of kidney failure in...
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Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake
Excessive fructose intake presents the major risk factor for metabolic cardiovascular disease. Perivascular adipose tissue (PVAT) is a metabolic...
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Potential Therapeutic Use of Coenzyme Q10 in Diabetes Mellitus and Its Complications: an Algorithm of Sco** Clinical Review
Results from investigations about the effect of coenzyme Q10 supplementation on diabetes mellitus and its related complications have varied and are...
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Effects of coenzyme Q10 supplementation on statin-induced myopathy: a meta-analysis of randomized controlled trials
BackgroundStatins can trigger a series of muscle-related adverse events, commonly referred to collectively as statin-induced myopathy. Although...
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New pathogenic variants in COQ4 cause ataxia and neurodevelopmental disorder without detectable CoQ10 deficiency in muscle or skin fibroblasts
COQ4 is a component of an enzyme complex involved in the biosynthesis of coenzyme Q 10 (CoQ 10 ), a molecule with primary importance in cell metabolism....
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Low coenzyme Q10 levels in patients with acute cardiovascular disease are associated with long-term mortality
Coenzyme Q10 (CoQ10) plays a potential role in the prevention and treatment of cardiovascular disease through improved cellular bioenergetics....
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The role of CoQ10 in embryonic development
Coenzyme Q10 (CoQ10) is a natural component widely present in the inner membrane of mitochondria. CoQ10 functions as a key cofactor for adenosine...
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Exploring mitochondrial biomarkers for Friedreich's ataxia: a multifaceted approach
This study presents an in-depth analysis of mitochondrial enzyme activities in Friedreich's ataxia (FA) patients, focusing on the Electron Transport...
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A novel variant of DNM1L expanding the clinical phenotypic spectrum: a case report and literature review
BackgroundMitochondrial diseases are heterogeneous in terms of clinical manifestations and genetic characteristics. The dynamin 1-like gene ( DNM1L )...
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PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis
Our previous studies have reported that a putative trypsin-like serine protease, PRSS37, is exclusively expressed in testicular germ cells during...
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A family segregating lethal neonatal coenzyme Q10 deficiency caused by mutations in COQ9
Primary CoQ 10 deficiency is a clinically and genetically heterogeneous, autosomal recessive disorder resulting from mutations in genes involved in...
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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia
Resistance to apoptosis in acute myeloid leukemia (AML) cells causes refractory or relapsed disease, associated with dismal clinical outcomes....
