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In-vitro model to mimic T cell subset change in human PDAC organoid co-culture
PurposeImmunotherapies have largely failed as treatment options for pancreatic ductal adenocarcinoma (PDAC). In this field, clinical translational...
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Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Tumor mass comprises not only cancer cells but also heterogeneous populations of immune and stromal cells, along with the components of the...
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Co-culture of human cryopreserved fragmented ovarian tissue with theca progenitor cells derived from theca stem cells
PurposeDespite the significant advances in the in vitro development of human primordial follicles, it is still a challenging approach with great...
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Acetate and propionate effects in response to LPS in a porcine intestinal co-culture model
BackgroundThe interest in acetate and propionate as short chain fatty acids (SCFA) derives from research on alternative strategies to the utilization...
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In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis
IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remodeling in IPF lungs is...
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Evaluation of a culture change program to reduce unprofessional behaviours by hospital co-workers in Australian hospitals
BackgroundUnprofessional behaviours between healthcare workers are highly prevalent. Evaluations of large-scale culture change programs are rare...
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Using a developed co-culture device to evaluate the proliferation of bone marrow stem cells by stimulation with platelet-rich plasma and electromagnetic field
BackgroundsBone marrow stem cell can differentiate to osteoblast by growth factors, pulsed low-intensity ultrasound and electric magnetic field. In...
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Investigation of the optimal light parameters for photobiomodulation to induce osteogenic differentiation of the human bone marrow stem cell and human umbilical vein endothelial cell co-culture
Bones have an important role in the human body with their complex nature. Mesenchymal stem cells and endothelial cells together support their unique...
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Strong culture, healthy lifestyles: a mixed methods feasibility study for a co-created afterschool cultural programme for Australian Aboriginal children
BackgroundHaving a strong connection to culture and Country is fundamental to the health and wellbeing of Australian Aboriginal children. The aim of...
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Middle manager responses to hospital co-workers’ unprofessional behaviours within the context of a professional accountability culture change program: a qualitative analysis
BackgroundThe critical role that middle managers play in enacting organisational culture change designed to address unprofessional co-worker...
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Ex vivo propagation in a novel 3D high-throughput co-culture system for multiple myeloma
PurposeMultiple myeloma (MM) remains an incurable hematologic malignancy which ultimately develops drug resistance and evades treatment. Despite...
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LINC01119 encapsulated by cancer-associated adipocytes-derived exosomes promotes M2 polarization of macrophages to induce immune escape in ovarian cancer in a 3D co-culture cell-based model
IntroductionIn the present study, we sought to clarify the role of LINC01119 delivered by cancer-associated adipocytes (CAAs)-derived exosomes...
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Effects of photobiomodulation on bone remodeling in an osteoblast–osteoclast co-culture system
The general bone anabolic effect of photobiomodulation (PBM) is largely accepted. As a result, PBM therapy is expected to be beneficial in the...
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Microfluidic Co-culture Platforms for Studying Osteocyte Regulation of Other Cell Types under Dynamic Mechanical Stimulation
Purpose of ReviewOsteocytes are the most abundant cell type in bone. These unique cells act primarily as mechanosensors and play crucial roles in the...
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Development of in-vitro maturation protocol for rat oocytes; under simple culture vs co-culture with cumulus cell monolayer and its developmental potential via Parthenogenetic/artificial activation
BackgroundMurine is the most abundantly used as laboratory animal models. There has been a tremendous amount of research including; their evolution,...
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Enhanced Synergistic-Antioxidant Activity of Melatonin and Tretinoin by Co-encapsulation into Amphiphilic Chitosan Nanocarriers: During Mice In Vitro Matured Oocyte/Morula-Compact Stage Embryo Culture Model
The use of exogenous antioxidants or the combination of them during in vitro oocyte/embryo culture media is reasonable. Co-delivery by nanocarrier...
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Anti-leukemia effect associated with down-regulated CD47 and up-regulated calreticulin by stimulated macrophages in co-culture
CD47 is over-expressed in Acute Myeloid Leukemia (AML) and functions as an inhibitory signal, suppressing phagocytosis by binding to signal...
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Different CO2 settings (6.0% vs 7.0%) do have an impact on extracellular pH of culture medium (pHe) and euploidy rates rather than on blastocyst development: a sibling oocyte study
ObjectiveTo determine whether euploidy rates and blastocyst development differ in a continuous culture medium under different CO 2 concentrations.
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Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture
BackgroundMost in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in...
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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs
Several in vitro models have been developed to mimic chronic lymphocytic leukemia (CLL) proliferation in immune niches; however, they typically do...
