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Evidence from ClinicalTrials.gov on the growth of Digital Health Technologies in neurology trials
Digital Health Technologies (DHTs) such as connected sensors offer particular promise for improving data collection and patient empowerment in...
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Update on the clinical trial landscape: analysis of ClinicalTrials.gov registration data, 2000–2020
BackgroundThe clinical trial landscape has evolved over the last two decades, shaped by advances in therapeutics and drug development and innovation...
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Reporting of the safety from allergic rhinitis trials registered on ClinicalTrials.gov and in publications: An observational study
BackgroundIncomplete and inconsistent reporting of adverse events (AEs) through multiple sources can distort impressions of the overall safety of the...
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A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.gov
Combination therapies have taken center stage for cancer treatment, however, there is a lack of a comprehensive portrait to quantitatively map the...
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Updated analysis of pediatric clinical studies registered in ClinicalTrials.gov, 2008–2019
BackgroundSince the national clinical trials registry ( ClinicalTrials.gov ) launched in February 2000, more than 360,000 research studies in the...
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Factors associated with North–South research collaboration focusing on HIV/AIDS: lessons from ClinicalTrials.gov
BackgroundA North–South (N–S) research collaboration is one way through which research capacity of develo** countries can be strengthened. Whereas...
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The automation of relevant trial registration screening for systematic review updates: an evaluation study on a large dataset of ClinicalTrials.gov registrations
BackgroundClinical trial registries can be used as sources of clinical evidence for systematic review synthesis and updating. Our aim was to evaluate...
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Definitions and elements of endpoints in phase III randomized trials for the treatment of COVID-19: a cross-sectional analysis of trials registered in ClinicalTrials.gov
BackgroundThere are several challenges in designing clinical trials for the treatment of novel infectious diseases, such as COVID-19. In particular,...
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Clinical trial reporting performance of thirty UK universities on ClinicalTrials.gov—evaluation of a new tracking tool for the US clinical trial registry
Clinical trial transparency forms the foundation of evidence-based medicine, and trial sponsors, especially publicly funded institutions such as...
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A Landscape Analysis of Post-Marketing Studies Registered in the EU PAS Register and ClinicalTrials.gov Focusing on Pregnancy Outcomes or Breastfeeding Effects: A Contribution from the ConcePTION Project
IntroductionA large proportion of medicine product labels lack information on safety in pregnancy and breastfeeding. To address this gap,...
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Current landscape of type 1 diabetes mellitus-related interventional clinical trials registered on ClinicalTrials.gov: a cross-sectional study
AimsA better understanding of the current features of type 1 diabetes mellitus (T1DM)-related interventional clinical trials is important for...
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The Landscape of COVID-19 Research in the United States: a Cross-sectional Study of Randomized Trials Registered on ClinicalTrials.Gov
ImportanceSARS-CoV-2 has infected over 200 million people worldwide, resulting in more than 4 million deaths. Randomized controlled trials are the...
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Registration of phase 3 crossover trials on ClinicalTrials.gov
BackgroundIn a randomized crossover trial, each participant is randomized to a sequence of treatments and treatment effect is estimated based on...
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Consistency of trial reporting between ClinicalTrials.gov and corresponding publications: one decade after FDAAA
The FDA Amendments Act (FDAAA) required that information for certain clinical trials, such as details about study design features and endpoints, as...
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Alzheimer's Disease and the Eye
This book is a compendium of the worldwide studies of Alzheimer’s disease utilizing the eye as a biomarker, or as a treatment method, that are...
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Characteristics and publication status of gastrointestinal endoscopy clinical trials registered in ClinicalTrials.gov
Background and aimsThis study aimed to examine the fundamental characteristics of gastrointestinal (GI) endoscopy trials and evaluate their...
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Some data quality issues at ClinicalTrials.gov
BackgroundClinical trial registries have been established as a form of public accountability. Sponsors ought to register their trials promptly and...
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