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Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China
BackgroundAsthma is a heterogeneous disease with variable symptoms, which presents with cough either as the sole or predominant symptom with or...
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Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2
Asthma represents a significant global challenge that affects individuals across all age groups and imposes substantial social and economic burden....
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LncRNA AK089514/miR-125b-5p/TRAF6 axis mediates macrophage polarization in allergic asthma
BackgroundMicro RNA (miRNA) plays important roles in macrophage polarization. However, the manner in which miRNA regulate macrophage polarization in...
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Upregulated microRNA-125b-5p in patients with asthma-COPD overlap mediates oxidative stress and late apoptosis via targeting IL6R/TRIAP1 signaling
BackgroundAmong patients with chronic obstructive pulmonary disease (COPD), some have features of both asthma and COPD—a condition categorized as...
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Predictive factors for obstructive sleep apnea in adults with severe asthma receiving biologics: a single-center cross-sectional study
PurposeTo evaluate the prevalence and potential predictors of obstructive sleep apnea (OSA) in a cohort of adults with severe asthma.
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Small airway dysfunction in patients with cough variant asthma: a retrospective cohort study
BackgroundCough variant asthma (CVA) is one of the special populations of asthma. The aim of the study was to compare small airways, the degree of...
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Pentraxin 3 promotes airway inflammation in experimental asthma
BackgroundPentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3...
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VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice
BackgroundAlthough Traditional Chinese Medicine (TCM) has been used for treating asthma for centuries, the understanding of its mechanism of action...
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Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA/CFA/LPS induced murine model
BackgroundAsthma is one of the most common chronic diseases that affects more than 300 million people worldwide. Though most asthma can be well...
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IRAK-M has effects in regulation of lung epithelial inflammation
BackgroundEpithelial barrier is important for asthma development by sha** immune responses. Airway expressing-IL-1 receptor-associated kinase...
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Airway inflammatory biomarkers in different asthma phenotypes
BackgroundAsthma is a diverse disease with various phenotypes. Correlation of clinical asthma phenotypes with their underlying inflammatory...
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Inhibition of airway remodeling and inflammatory response by Icariin in asthma
BackgroundIcariin (ICA) is the major active ingredient extracted from Chinese herbal medicine Epimedium, which has the effects of improving...
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Evaluation of neuropsychiatric comorbidities and their clinical characteristics in Chinese children with asthma using the MINI kid tool
BackgroundThe mental health and quality of life in children with asthma have attracted widespread attention. This study focused on the evaluation of...
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Pulmonale neuroendokrine Tumoren
Clinical issueNeuroendocrine neoplasms of the lung are a heterogenous tumor group. The pathological classification comprises diffuse idiopathic...
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TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway
BackgroundChildhood asthma is a common respiratory disease characterized by airway inflammation. Tumor necrosis factor-α-induced protein 8-like 2...
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A retrospective study of clinical features of cough variant asthma in Chinese adults
BackgroundClinical features of cough variant asthma (CVA) in Chinese adults are largely uncertain.
MethodsA total of 303 patients newly diagnosed as...
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Candida in COVID-19: Gut-Lung Axis, Dysbiosis, and Infections
Purpose of ReviewThis review discusses the connections between the gut-lung axis, gut and respiratory tract dysbiosis, and Candida bloodstream,...
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β2-Adrenoceptor Activation Stimulates IL-6 Production via PKA, ERK1/2, Src, and Beta-Arrestin2 Signaling Pathways in Human Bronchial Epithelia
Objectiveβ 2 -Adrenoceptor agonists are widely used to treat asthma because of their bronchial-dilation effects. We previously reported that...
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Eosinophile Dermatosen
Eosinophilic dermatoses are a heterogeneous group of rare diseases that histopathologically display the defining pattern of an eosinophil-rich dermal...
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Patients with hereditary angioedema and their treatment patterns in Germany: a Delphi consensus study
BackgroundLittle is known about how many patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) receive on-demand and/or...