Search
Search Results
-
Clinical significance of circulating neutrophils and lymphocyte subsets in newly diagnosed patients with diffuse large B-cell lymphoma
Lymphocytes play crucial roles in tumor surveillance in diffuse large B-cell lymphoma (DLBCL). Neutrophil-to-lymphocyte ratio (NLR), a biomarker for...
-
Neutrophils in cancer: dual roles through intercellular interactions
Neutrophils, the most abundant immune cells in human blood, play crucial and diverse roles in tumor development. In the tumor microenvironment (TME),...
-
Pathogenic role and clinical significance of neutrophils and neutrophil extracellular traps in idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune diseases characterized by muscle damage and extramuscular...
-
Understanding the functional relevance of oral neutrophils, phenotype and properties in OSCC
Neutrophils are the predominant white blood cells (WBC) that are recruited to the sites of inflammation and infection. They are acknowledged to...
-
The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils
The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and...
-
HBeAg induces neutrophils activation impairing NK cells function in patients with chronic hepatitis B
BackgroundThe role of neutrophils in hepatitis B virus (HBV) infection has been a subject of debate due to their involvement in antiviral responses...
-
Causal association between circulating blood cell traits and pulmonary embolism: a mendelian randomization study
BackgroundPulmonaryembolism (PE) is a life-threatening thromboembolic disease for which there is limited evidence for effective prevention and...
-
Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis
Pancreatitis is an inflammatory disease, which is triggered by adverse events in acinar cells of the pancreas. After the initial injury, infiltration...
-
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury
Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and...
-
FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury
BackgroundNeutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI)....
-
Interplay between tumor-derived factors and tumor-associated neutrophils: opportunities for therapeutic interventions in cancer
Neutrophils have emerged as important players in the tumor microenvironment, largely attributed to their plasticity and heterogeneity. Evidence...
-
Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the CNS characterized by the production of disease-specific autoantibodies...
-
Semaglutide modulates prothrombotic and atherosclerotic mechanisms, associated with epicardial fat, neutrophils and endothelial cells network
BackgroundObesity has increased in recent years with consequences on diabetes and other comorbidities. Thus, 1 out of 3 diabetic patients suffers...
-
Sepsis in elderly patients: the role of neutrophils in pathophysiology and therapy
Sepsis is among the most important causes of mortality, particularly within the elderly population. Sepsis prevalence is on the rise due to different...
-
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion
BackgroundGallbladder cancer (GBC) is the most common and lethal malignancy of the biliary tract that lacks effective therapy. In many GBC cases,...
-
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils
Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial...
-
Neutrophils seeking new neighbors: radiotherapy affects the cellular framework and the spatial organization in a murine breast cancer model
Neutrophils are known to contribute in many aspects of tumor progression and metastasis. The presence of neutrophils or neutrophil-derived mediators...
-
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
BackgroundImpaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfunctional immune...
-
Glutathione peroxidase 3 is a novel clinical diagnostic biomarker and potential therapeutic target for neutrophils in rheumatoid arthritis
BackgroundNeutrophils have a critical role in the pathogenesis of rheumatoid arthritis (RA) with immune system dysfunction. However, the molecular...
-
SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer
BackgroundThe tumor microenvironment (TME) plays a crucial role in various aspects of breast cancer development and metastasis. Nevertheless, the...
