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Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis
Accurate detection of circulating tumor cells (CTCs) in blood and non-blood body fluids enables generation of deterministic cancer diagnosis and...
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and...
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Hematological profiles of newborns of mothers with hypertensive disorders of pregnancy delivered at the University of Gondar comprehensive specialized hospital: a comparative cross-sectional study
BackgroundHypertensive disorders in pregnancy can cause prenatal placental perfusion with insufficient blood supply to the fetus, resulting in fetal...
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Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15
Recombinant agonists that activate co-stimulatory and cytokine receptors have shown limited clinical anticancer utility, potentially due to narrow...
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The mesenchymal circulating tumor cells as biomarker for prognosis prediction and supervision in hepatocellular carcinoma
PurposeHepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of death worldwide. Accurate prognosis prediction tools...
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Noninvasive Prenatal Diagnostics: Recent Developments Using Circulating Fetal Nucleated Cells
Purpose of ReviewThe purpose of this review is to highlight recent research advances in noninvasive prenatal diagnostic methods.
Recent Findings ...
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Association of placental histology and neonatal hematologic outcomes
ObjectiveThe objective of the paper was to investigate how neonatal hematologic outcomes vary by major placental histopathology categories.
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NRBC concentrations over time in neonates with moderate to severe neonatal encephalopathy with and without sentinel events
ObjectiveTo study the serum concentrations of nucleated red blood cells (NRBC) over time in neonates with moderate to severe neonatal encephalopathy...
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Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma
BackgroundLipid droplets (LDs) as major lipid storage organelles are recently reported to be innate immune hubs. Perilipin-3 (PLIN3) is indispensable...
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Recent progress in the treatment of sickle cell disease: an up-to-date review
BackgroundSickle cell disease is a fatal systemic condition characterized by acute painful episodes, persistent anemia, ongoing organ damage, organ...
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Circulating miRNAs and tissue iron overload in transfusion-dependent β-thalassemia major: novel predictors and follow-up guide
Tissue iron overload is a life-threatening scenario in children with transfusion-dependent β-thalassemia major, miRNAs that are involved in iron...
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Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion
The spleen contributes importantly to myocardial ischemia/reperfusion (MI/R) injury. Nucleotide-binding oligomerization domain-like receptor family...
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Cell-based non-invasive prenatal testing for monogenic disorders: confirmation of unaffected fetuses following preimplantation genetic testing
PurposeProof of concept of the use of cell-based non-invasive prenatal testing (cbNIPT) as an alternative to chorionic villus sampling (CVS)...
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Neonatal hematological parameters: the translational aspect of developmental hematopoiesis
Hematopoiesis is a process constantly evolving from fetal life through adulthood. Neonates present with qualitative and quantitative differences in...
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Cell-Free Fetal DNA Increases Prior to Labor at Term and in a Subset of Preterm Births
Cell-free fetal DNA in the maternal circulation has been associated with the onset of labor at term. Moreover, clinical studies have suggested that...
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Synchronous plasma cell neoplasm and B lymphoblastic leukemia/lymphoma at initial presentation: first report of an unusual association with a good outcome
A synchronous diagnosis of a plasma cell neoplasm (PCN) and a non-plasma cell hematologic malignancy is very rare. We report what we believe is the...
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DNA methylome profiling of circulating tumor cells in lung cancer at single base-pair resolution
DNA methylation plays a pivotal role in regulating cellular processes, and altered DNA methylation pattern is a general hallmark of cancer. However,...
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Development of the immune system in the human embryo
AbstractThe fetal immune system is highly specialized which is to generate both tolerogenic and protective immune responses to tolerate both self-...
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Technologies for circulating tumor cell separation from whole blood
The importance of early cancer diagnosis and improved cancer therapy has been clear for years and has initiated worldwide research towards new...
