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1. Characteristics and clinical treatment outcomes of chronic hepatitis B children with coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg

   Background

   The coexistence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) represents an uncommon serological pattern...

   Ying** Gu, Shuangjie Li, ... Songxu Peng in BMC Medicine

   Article Open access 20 February 2024
   

2. A conceptual model for chronic hepatitis B and content validity of the Hepatitis B Quality of Life (HBQOL) instrument

   Background

   There is increased emphasis on incorporating patient perspectives and patient-relevant endpoints in drug development. We developed a...

   Jane Abbott, Natalie V. J. Aldhouse, ... Patrick T. Kennedy in Journal of Patient-Reported Outcomes

   Article Open access 04 March 2024
   

3. Trends of hepatitis B virus genotype distribution in chronic hepatitis B patients in Japan

   Background

   Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Japan, genotypes B...

   Kazumasa Sakamoto, Kiyoaki Ito, ... Masashi Yoneda in Journal of Gastroenterology

   Article 29 September 2022
   

4. Associations of Wnt5a expression with liver injury in chronic hepatitis B virus infection

   Background

   Aberrant Wnt5a expression contributes to immunity, inflammation and tissue damage. However, it remains unknown whether Wnt5a is associated...

   **ang-Fen Ji, Qi Zhou, ... Kai Wang in BMC Infectious Diseases

   Article Open access 07 December 2023
   

5. Prevalence and genotypes distribution of virus hepatitis B and hepatitis delta virus in chronic liver diseases in Kazakhstan

   Background

   The geographical distribution of hepatitis B virus (HBV) and hepatitis D virus (HDV) genotypes is uneven and has its own clinical and...

   Bibigul S. Ilyassova, Balzhan Abzhaparova, ... Shokan Kaniyev in BMC Infectious Diseases

   Article Open access 14 August 2023
   

6. Hepatitis B virus infection as a risk factor for chronic kidney disease: a systematic review and meta-analysis

   Background

   Currently, several studies have observed that chronic hepatitis B virus infection is associated with the pathogenesis of kidney disease....

   Dan**g Chen, Rong Yu, ... **an-e Peng in BMC Infectious Diseases

   Article Open access 22 June 2024
   

7. Perspective on Emerging Therapies to Achieve Functional Cure of Chronic Hepatitis B

   Purpose of Review

   Advancements in our understanding of the hepatitis B viral (HBV) life cycle have paved the way for novel approaches to treat HBV...

   Harish Gopalakrishna, Marc G. Ghany in Current Hepatology Reports

   Article Open access 10 February 2024
   

8. Low Rate of Hepatitis B Reactivation Among Patients with Chronic Hepatitis C During Direct Acting Antiviral Therapy

   Background and Aims

   Hepatitis B virus (HBV) reactivation has been reported in patients co-infected with hepatitis C virus (HCV) during direct acting...

   Nehna Abdul Majeed, Ahmad Samer Alawad, ... Marc G. Ghany in Digestive Diseases and Sciences

   Article 06 April 2023

9. HBeAg induces neutrophils activation impairing NK cells function in patients with chronic hepatitis B

   Background

   The role of neutrophils in hepatitis B virus (HBV) infection has been a subject of debate due to their involvement in antiviral responses...

   Zhiqian Feng, Junliang Fu, ... Fu-Sheng Wang in Hepatology International

   Article 03 June 2024
   

10. Latest insights into the epidemiology, characteristics, and therapeutic strategies of chronic hepatitis B patients in indeterminate phase

    As a hepatotropic virus, hepatitis B virus (HBV) can establish a persistent chronic infection in the liver, termed, chronic hepatitis B (CHB), which...

    Junye Liu, Yan Yu, ... **g Lv in European Journal of Medical Research

    Article Open access 21 June 2024
    

11. Correlation between quantitative HBsAg and quantitative HBV DNA in chronic hepatitis B patients: a systematic review and meta-analysis

    Background

    HBV DNA assays have several limitations including being expensive and not widely available. Detection of HBsAg in serum has been the...

    Ummi Maimunah, Puspa Wardhani, ... Andrio Palayukan in Egyptian Liver Journal

    Article Open access 21 May 2024
    

12. The scientific basis of combination therapy for chronic hepatitis B functional cure

    Functional cure of chronic hepatitis B (CHB) — or hepatitis B surface antigen (HBsAg) loss after 24 weeks off therapy — is now the goal of treatment,...

    Seng Gee Lim, Thomas F. Baumert, ... Fabien Zoulim in Nature Reviews Gastroenterology & Hepatology

    Article 11 January 2023
    

13. The non-invasive serum biomarkers contributes to indicate liver fibrosis staging and evaluate the progress of chronic hepatitis B

    Background

    This study aimed to evaluate the diagnostic abilities of the non-invasive serum biomarkers to predict liver fibrosis staging and evaluate...

    Shaoxiong Zeng, Zhenzhen Liu, ... Siwei Tan in BMC Infectious Diseases

    Article Open access 26 June 2024
    

14. Incidence and predictors of elevated postpartum alanine aminotransferase in chronic hepatitis B mothers: a prospective study protocol

    Background

    The majority of HBeAg-positive mothers with chronic hepatitis B have high levels of viremia and inactive disease with normal alanine...

    Shi OuYang, Ziren Chen, ... Calvin Q. Pan in BMC Gastroenterology

    Article Open access 11 November 2023
    

15. Functional cure is associated with younger age in children undergoing antiviral treatment for active chronic hepatitis B

    Background and Aims

    Functional cure is difficult to achieve using current antiviral therapies; moreover, limited data are available regarding...

    Min Zhang, **g Li, ... Fu-Sheng Wang in Hepatology International

    Article Open access 20 February 2024
    

16. B-Clear Phase 2b Study Design: Establishing the Efficacy and Safety of Bepirovirsen in Patients with Chronic Hepatitis B Virus Infection

    Introduction

    Bepirovirsen (GSK3228836) is an antisense oligonucleotide that induced rapid and prolonged hepatitis B surface antigen (HBsAg) reduction...

    Jennifer Cremer, Robert Elston, ... Dickens Theodore in Advances in Therapy

    Article Open access 01 July 2023
    

17. Evidence-Based Strategies for Micro-elimination of Chronic Hepatitis B Virus Infection

    Purpose of Review

    Hepatitis B (HBV) remains a health threat around the world. Hepatitis C is closer to meeting the World Health Organization’s 2030...

    Katerina Roma, Mark Hsu, ... Robert Gish in Current Hepatology Reports

    Article Open access 29 July 2023

18. Emerging Therapies for Chronic Hepatitis B and the Potential for a Functional Cure

    Worldwide, an estimated 296 million people are living with chronic hepatitis B virus (HBV) infection, with a significant risk of morbidity and...

    Ming-Ling Chang, Yun-Fan Liaw in Drugs

    Article 11 March 2023
    

19. Prognostic Effects of Liver Fibrosis and Steatosis Determined Using Transient Elastography in Patients with Chronic Hepatitis B or C

    Background

    The prognostic effects of liver fibrosis and steatosis in patients with chronic hepatitis B or C are unclear. We investigated the...

    Chun-Li Wang, Chien-Hao Huang, ... Shang-Hung Chang in Digestive Diseases and Sciences

    Article 18 April 2023
    

20. Immune therapies against chronic hepatitis B

    Patients with chronic hepatitis B (CHB) represent a living and permanent reservoir of hepatitis B virus (HBV). Millions of these CHB patients will...

    Sheikh Mohammad Fazle Akbar, Osamu Yoshida, Yoichi Hiasa in Journal of Gastroenterology

    Article Open access 16 June 2022