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Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Chronic cough is characterized by a state of cough hypersensitivity. We analyze the process of transpiration, by which water appears to evaporate...
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Drugs Targeting Cough Receptors: New Therapeutic Options in Refractory or Unexplained Chronic Cough
Refractory chronic cough is a disabling disease with very limited therapeutic options. A better understanding of cough pathophysiology has led to the...
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Cough hypersensitivity and chronic cough
Chronic cough is globally prevalent across all age groups. This disorder is challenging to treat because many pulmonary and extrapulmonary conditions...
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Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life
PurposeChronic cough (CC), defined as a cough persisting ≥ 8 weeks, can have a substantial negative impact on health-related quality of life (HRQoL)....
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The Therapeutic Landscape in Chronic Cough
In recent years, there has been a substantial increase in the development of antitussive therapies and the first new therapy, gefapixant has been...
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An observational study to understand burden and cost of care in adults diagnosed with refractory chronic cough (RCC) or unexplained chronic cough (UCC)
BackgroundRefractory and unexplained chronic cough (RCC and UCC) necessitate frequent referral for specialist evaluations, but data on healthcare...
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Cough Response to High-Dose Inhaled Corticosteroids in Patients with Chronic Cough and Fractional Exhaled Nitric Oxide Levels ≥ 25 ppb: A Prospective Study
This study aimed to investigate the effects of high-dose inhaled corticosteroids (ICS) on chronic cough patients with elevated fractional exhaled...
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Feasibility and Utility of a Smartphone Application-Based Longitudinal Cough Monitoring in Chronic Cough Patients in a Real-World Setting
PurposeThis study evaluated the feasibility and utility of longitudinal cough frequency monitoring with the Hyfe Cough Tracker, a mobile application...
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The Severity of Chronic Cough Diary (SCCD): development and content validation of a novel patient-reported outcome instrument for evaluating the symptom experience of chronic cough
BackgroundRefractory chronic cough (RCC), a cough lasting longer than 8 weeks with an unexplained underlying etiology and unresponsive to...
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Prevalence, clinical characteristics, and disease burden of chronic cough in Italy: a cross-sectional study
BackgroundChronic cough has been associated with reduced health-related quality of life, negative impacts on sleep, work, and other daily activities,...
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Illuminating Airway Nerve Structure and Function in Chronic Cough
Airway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulation of airway nerves...
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Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study
PurposeThe Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in...
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Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial
ObjectiveThe purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough...
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Chronic cough diagnosis, treatment, and referral practices among family physicians in the United States: a survey study
BackgroundCough is one of the most common presenting problems for patients in primary care and is largely managed in primary care clinical settings....
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Chronic cough in postmenopausal women and its associations to climacteric symptoms
BackgroundPostmenopausal women often have chronic cough. Hormonal changes might be affecting lung function and the mucous membrane of the airways,...
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Validation and Meaningful Change Thresholds for an Objective Cough Frequency Measurement in Chronic Cough
PurposeObjective cough frequency is used to assess efficacy of chronic cough (CC) treatments. The objective of this study was to explore the...
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Burden of Disease Associated with Refractory and Unexplained Chronic Cough in Canada: Results from a National Survey
IntroductionChronic cough (persisting for ≥ 8 weeks) is a common disorder that includes refractory chronic cough (RCC; cough that persists despite...
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Chronic Cough as a Genetic Neurological Disorder? Insights from Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)
Chronic cough is common, and in many cases unexplained or refractory to otherwise effective treatment of associated medical conditions. Cough...
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Evaluation of Chronic Cough in Children Using Management Algorithm: A Prospective Cohort Study
ObjectiveTo assess the use of a standardized evaluation algorithm [American College of Chest Physician (ACCP) 2006] in children with chronic cough.
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Clinical characteristics and effects of inhaled corticosteroid in patients with post-COVID-19 chronic cough during the Omicron variant outbreak
BackgroundChronic cough is a common symptom in patients post the coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate the...
