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Involvement of the ipsilateral-to-the-pain anterior–superior hypothalamic subunit in chronic cluster headache
BackgroundDespite hypothalamus has long being considered to be involved in the pathophysiology of cluster headache, the inconsistencies of previous...
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Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache
BackgroundIt is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and whether it is a...
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Debate: Are cluster headache and migraine distinct headache disorders?
Cluster headache and migraine are regarded as distinct primary headaches. While cluster headache and migraine differ in multiple aspects such as...
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CGRP-Targeted Therapy for Episodic and Chronic Cluster Headache
Purpose of ReviewChronic cluster headache (CH) substantially affects patients’ quality of life, and treatment remains challenging. The current...
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Preventive treatment of refractory chronic cluster headache: systematic review and meta-analysis
BackgroundPreventive treatment for refractory chronic cluster headache (rCCH) is challenging and many therapies have been tried.
Objective ...
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Cluster Headache Impact Questionnaire (CHIQ) – a short measure of cluster headache related disability
BackgroundCluster headache (CH) is a severe, highly disabling primary headache disorder. However, there is little research on CH-related disability,...
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Ketamine as Treatment for Cluster Headache: A Systematic Review of Literature and a Case Series
IntroductionCluster headache is a severe and debilitating neurological condition characterized by intense, excruciating pain with a significant...
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The Prevalence and Clinical Phenotypes of Cluster Headache in Relation with Latitude
Purpose of ReviewPrevious studies have indicated a possible link between the prevalence of cluster headache (CH) and sunlight exposure. However, this...
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MERTK in the rat trigeminal system: a potential novel target for cluster headache?
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features....
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Neurostimulation Treatment in Chronic Cluster Headache—a Narrative Review
Purpose of ReviewIn this narrative review, the current literature on neurostimulation methods in the treatment of chronic cluster headache is...
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Cluster headache and kynurenines
BackgroundThe glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites...
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Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article
AimTreatment for cluster headache is currently based on a trial-and-error approach. The available preventive treatment is unspecific and based on few...
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Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions
BackgroundNew guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional...
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The HortONS study. Treatment of chronic cluster headache with transcutaneous electrical nerve stimulation and occipital nerve stimulation: study protocol for a prospective, investigator-initiated, double-blinded, randomized, placebo-controlled trial
BackgroundChronic cluster headache (CCH) is a debilitating primary headache disorder. Occipital nerve stimulation (ONS) has shown the potential to...
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One-year prevalence of cluster headache, hemicrania continua, paroxysmal hemicrania and SUNCT in Norway: a population-based nationwide registry study
BackgroundThere is lack of population-based studies evaluating the prevalence of paroxysmal hemicrania, hemicrania continua and short-lasting...
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Validation of the Italian version of the Cluster Headache Impact Questionnaire (CHIQ)
BackgroundThe Cluster Headache Impact Questionnaire (CHIQ) is a specific and easy-to-use questionnaire to assess the current impact of cluster...
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Translating the Cluster Headache Quality of Life Questionnaire (CHQ) from English to Dutch with the TRAPD method
ObjectiveCluster headache is associated with a decreased quality of life (QoL). The increased focus on patient-reported outcome measures (PROMS) has...
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Galcanezumab effectiveness on comorbid cluster headache and chronic migraine: a prospective case series
BackgroundCluster headache (CH) and migraine are recurrent painful primary cephalalgies, typically with different clinical appearance and some shared...
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The economic and personal burden of cluster headache: a controlled cross-sectional study
BackgroundCluster headache is a less-prevalent primary headache disorder but is overrepresented with regards to use of health care and social...
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Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan
BackgroundCluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies...
