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Functional cure is associated with younger age in children undergoing antiviral treatment for active chronic hepatitis B
Background and AimsFunctional cure is difficult to achieve using current antiviral therapies; moreover, limited data are available regarding...
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Latest insights into the epidemiology, characteristics, and therapeutic strategies of chronic hepatitis B patients in indeterminate phase
As a hepatotropic virus, hepatitis B virus (HBV) can establish a persistent chronic infection in the liver, termed, chronic hepatitis B (CHB), which...
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Associations of Wnt5a expression with liver injury in chronic hepatitis B virus infection
BackgroundAberrant Wnt5a expression contributes to immunity, inflammation and tissue damage. However, it remains unknown whether Wnt5a is associated...
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Low Rate of Hepatitis B Reactivation Among Patients with Chronic Hepatitis C During Direct Acting Antiviral Therapy
Background and AimsHepatitis B virus (HBV) reactivation has been reported in patients co-infected with hepatitis C virus (HCV) during direct acting...
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Characteristics and clinical treatment outcomes of chronic hepatitis B children with coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg
BackgroundThe coexistence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) represents an uncommon serological pattern...
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Perspective on Emerging Therapies to Achieve Functional Cure of Chronic Hepatitis B
Purpose of ReviewAdvancements in our understanding of the hepatitis B viral (HBV) life cycle have paved the way for novel approaches to treat HBV...
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A conceptual model for chronic hepatitis B and content validity of the Hepatitis B Quality of Life (HBQOL) instrument
BackgroundThere is increased emphasis on incorporating patient perspectives and patient-relevant endpoints in drug development. We developed a...
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Correlation between quantitative HBsAg and quantitative HBV DNA in chronic hepatitis B patients: a systematic review and meta-analysis
BackgroundHBV DNA assays have several limitations including being expensive and not widely available. Detection of HBsAg in serum has been the...
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Prevalence and outcome of chronic hepatitis C patients admitted with COVID-19 to intensive care units: a blessing in disguise
BackgroundManaging COVID-19 pneumonia is, in reality, one of the biggest challenges in the history of intensive care medicine. The link between...
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Seroprevalence of hepatitis B and C virus among highly active antiretroviral therapy experienced children in Gondar, Ethiopia
BackgroundGlobally, chronic viral hepatitis is the cause of mortality alongside human immunodeficiency virus / acquired immunodeficiency syndrome and...
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The scientific basis of combination therapy for chronic hepatitis B functional cure
Functional cure of chronic hepatitis B (CHB) — or hepatitis B surface antigen (HBsAg) loss after 24 weeks off therapy — is now the goal of treatment,...
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Chronic Viral Hepatitis in Elite Athletes: Approaches to Risk Assessment, Prevention and Management
Elite athletes who participate in contact sports are at risk of bleeding injuries, leading to transmission of blood-borne viruses including hepatitis...
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Chronic viral hepatitis accelerates lung function decline in smokers
Although hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotrophic viruses, they may affect pulmonary diseases. The purpose of this study...
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Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B
ObjectiveTo evaluate the diagnostic accuracy of aspartate aminotransferase(AST)/ alanine transaminase (ALT), AST to platelet ratio index (APRI),...
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Evidence-Based Strategies for Micro-elimination of Chronic Hepatitis B Virus Infection
Purpose of ReviewHepatitis B (HBV) remains a health threat around the world. Hepatitis C is closer to meeting the World Health Organization’s 2030...
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Emerging Therapies for Chronic Hepatitis B and the Potential for a Functional Cure
Worldwide, an estimated 296 million people are living with chronic hepatitis B virus (HBV) infection, with a significant risk of morbidity and...
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Symptoms of Liver Disease During Tenofovir Therapy With or Without Peginterferon: Results from the Hepatitis B Research Network Immune Active Trial
AimsEvaluate patient-reported liver symptoms during treatment for chronic hepatitis B viral (HBV) infection and associations between changes in...
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Chronic hepatitis E in an elderly immunocompetent patient who achieved a sustained virologic response with ribavirin treatment
A woman in her late 70 s was diagnosed with liver injury at a health examination. Despite treatment with ursodeoxycholic acid at a nearby hospital,...
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Patient Biochemistry and Treatment Need in Chronic Hepatitis B Virus Infection Across Three Continents: Retrospective Cross-Sectional Cohort Studies
IntroductionChronic hepatitis B virus (HBV) infection is associated with significant global morbidity and mortality. Low treatment rates are observed...
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Direct-Acting Antiviral Therapy for Patients with Chronic Hepatitis C Infection and Decompensated Cirrhosis
Patients with chronic hepatitis C virus (HCV) infection and decompensated cirrhosis are an important population for antiviral therapy yet...