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Exploring the epigenetic profile of ID4 in breast cancer: bioinformatic insights into methylation patterns and chromatin accessibility dynamics
PurposeInhibitor of differentiation 4 (ID4) is a dominant-negative regulator of basic helix–loop–helix (bHLH) transcription factors. The expression...
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Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma
PurposeGrowth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like...
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Co-profiling reveals distinct patterns of genomic chromatin accessibility and gene expression in pulmonary hypertension caused by chronic hypoxia
IntroductionAberrant gene expression is a key mechanism underlying pulmonary hypertension (PH) development. The alterations of genomic chromatin...
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Characterization of chromatin accessibility in psoriasis
The pathological hallmarks of psoriasis involve alterations in T cell genes associated with transcriptional levels, which are determined by chromatin...
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Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy
BackgroundDiabetic cardiomyopathy (DCM) poses a growing health threat, elevating heart failure risk in diabetic individuals. Understanding DCM is...
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Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and...
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Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction
Chimeric antigen receptor T cells (CAR-T) therapy has achieved remarkable therapeutic success in treating a variety of hematopoietic malignancies....
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Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration
Tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) exhibit characteristic neuronal and glial inclusions of...
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Three-dimensional chromatin landscapes in MLLr AML
Rearrangements of the mixed lineage leukemia (MLLr) gene are frequently associated with aggressive acute myeloid leukemia (AML). However, the...
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Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks
Acute lymphoblastic leukemia (ALL) is a hematopoietic malignancy comprised of molecular subtypes largely characterized by aneuploidy or recurring...
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Sperm chromatin accessibility’s involvement in the intergenerational effects of stress hormone receptor activation
Dexamethasone is a stress hormone receptor agonist used widely in clinics. We and others previously showed that paternal administration of...
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Oncogenic dependency on SWI/SNF chromatin remodeling factors in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy arising from immature thymocytes. Unlike well-known oncogenic transcription...
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Nonlinear relationship between chromatin accessibility and estradiol-regulated gene expression
Chromatin accessibility is central to basal and inducible gene expression. Through ATAC-seq experiments in estrogen receptor-positive (ER+) breast...
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The roles of chromatin regulatory factors in endometriosis
PurposeEndometriosis is an estrogen-dependent inflammatory disease and one of the most common gynecological diseases in women of reproductive age....
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Remembering through the genome: the role of chromatin states in brain functions and diseases
Chromatin is the physical substrate of the genome that carries the DNA sequence and ensures its proper functions and regulation in the cell nucleus....
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The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance
RNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We...
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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization
HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the...
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Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies
Multiple genomic and proteomic studies have suggested that peripheral blood mononuclear cells (PBMCs) respond to tumor secretomes and thus could...
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InterLINCing Chromatin Organization and Mechanobiology in Laminopathies
Purpose of reviewIn this review, we explore the chromatin-related consequences of laminopathy-linked mutations through the lens of...
