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PAC1 deficiency reduces chondrogenesis in atherosclerotic lesions of hypercholesterolemic ApoE-deficient mice
BackgroundInduction of chondrogenesis is associated with progressive atherosclerosis. Deficiency of the ADCYAP1 gene encoding pituitary adenylate...
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The efficacy of autologous matrix-induced chondrogenesis (AMIC) for osteochondral lesions of the talus in the mid-long term: a systematic review and meta-analysis
PurposeThe objective of this study was to provide a comprehensive review of the existing literature regarding the treatment of osteochondral lesions...
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A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMIC®) over microfracture: 10-year follow-up
PurposeAutologous matrix-induced chondrogenesis (AMIC ® ) and microfracture are established treatments for focal chondral defects in the knee, but...
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Human umbilical cord mesenchymal stem cells promoting knee joint chondrogenesis for the treatment of knee osteoarthritis: a systematic review
PurposeThe onset of OA is affected by a variety of factors, which eventually lead to the loss of cartilage in the joints, the formation of...
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Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis
BackgroundTeratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of...
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Positive outcomes following Autologous Matrix-Induced Chondrogenesis (AMIC) in the treatment of retropatellar chondral lesions: a retrospective analysis of a patient registry
BackgroundThe patellofemoral joint is a challenging environment for treating chondral defects. Among the surgical options for the treatment of...
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Satisfactory patient-reported outcomes in patients treated with impaction bone grafting and autologous matrix-induced chondrogenesis for osteochondral knee defects
PurposeOsteochondral knee defects usually affect young, active patients and may alter knee biomechanics and progressively lead to joint degeneration....
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One-stage cartilage repair using the autologous matrix-induced chondrogenesis combined with simultaneous use of autologous adipose tissue graft and adipose tissue mesenchymal cells technique: clinical results and magnetic resonance imaging evaluation at five-year follow-up
PurposeTo evaluate medium-term outcomes of knee cartilage defects repair by autologous matrix-induced chondrogenesis combined with simultaneous use...
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Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification
Ankylosing spondylitis (AS) is chronic inflammatory arthritis with a progressive fusion of axial joints. Anti-inflammatory treatments such as...
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Autologous matrix-induced chondrogenesis plus peripheral blood concentrate (AMIC+PBC) in chondral defects of the first metatarsophalangeal joint
ObjectiveChondral restoration in chondral defects of the 1st metatarsophalangeal joint (MTP1) using autologous matrix-induced chondrogenesis plus...
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Matrix-induced chondrogenesis is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee: a systematic review
PurposeThe purpose of this study was to perform a systematic review of randomized controlled trials comparing the results of matrix-induced...
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Role of nuclear factor of activated T cells in chondrogenesis osteogenesis and osteochondroma formation
PurposeNuclear factor of activated T cells (NFATc) are transcription factors that play a function in the immune response and in osteoclast...
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LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice
The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion. Here, we report that...
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Chondrogenesis Defines Future Skeletal Patterns Via Cell Transdifferentiation from Chondrocytes to Bone Cells
Purpose of ReviewThe goal of this review is to obtain a better understanding of how chondrogenesis defines skeletal development via cell...
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Comparative in vitro treatment of mesenchymal stromal cells with GDF-5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy
PurposeHypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis....
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Aqueous extract of Arctium lappa L. root (burdock) enhances chondrogenesis in human bone marrow-derived mesenchymal stem cells
BackgroundArctium lappa L. root (burdock root) has long been recommended for the treatment of different diseases in traditional Chinese medicine....
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Identifying the key genes regulating mesenchymal stem cells chondrogenic differentiation: an in vitro study
BackgroundMesenchymal stem cells (MSCs) possess the potential to differentiate into chondrocytes, which makes them an ideal source for healing...
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Periostin splice variants affect craniofacial growth by influencing chondrocyte hypertrophy
IntroductionPeriostin, an extracellular matrix protein, plays an important role in osteogenesis and is also known to activate several signals that...
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Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/β-catenin signaling
BackgroundGEM (GTP-binding protein overexpressed in skeletal muscle) is one of the atypical small GTPase subfamily members recently identified as a...
