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Impact of Neutrophil Extracellular Traps Identified by Citrullinated Histone H3 Immunohistochemistry for Postoperative Prognosis in Patients with Extrahepatic Cholangiocarcinomas
BackgroundNeutrophil extracellular traps (NETs) are extracellular chromatin structures composed of cytoplasmic, granular, and nuclear components of...
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Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses
BackgroundImmunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective...
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Portal vein arterialization: a possibility in cholangiocarcinomas infiltrating the right hepatic artery?
Portal vein arterialization (PVA) in advanced cholangiocarcinoma (CCA) is an emerging field of study too little explored despite its potential...
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Role of Intraoperative Frozen Section Assessment of Proximal Bile Duct Margins and the Impact of Additional Re-Resection in Perihilar Cholangiocarcinomas
Intraoperative frozen section (FS) analysis to assess the bile duct margin status is commonly used to assess the completeness of resection during...
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Real-World Data on Ivosidenib in Patients with Previously Treated Isocitrate Dehydrogenase 1-Mutated Intrahepatic Cholangiocarcinomas: An Early Exploratory Analysis
BackgroundThe results of the phase III ClarIDHy trial have led to US FDA approval of ivosidenib as a therapeutic option for patients with locally...
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Multiple cholangiocarcinomas in the intrahepatic and extrahepatic biliary tree due to dichloromethane exposure: a case report
BackgroundAn outbreak of cholangiocarcinoma in Japan has led to widespread concern among workers in printing plants. In March 2013, the Japanese...
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Clinical results of the EVESOR trial, a multiparameter phase I trial of everolimus and sorafenib combination in solid tumors
PurposeEverolimus (EVE) and sorafenib (SOR) combination was associated with synergistic activity in preclinical models. However, previous clinical...
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Time to Recurrence After Surgical Resection and Survival After Recurrence Among Patients with Perihilar and Distal Cholangiocarcinomas
BackgroundThe differences between perihilar cholangiocarcinoma (PHCC) and distal cholangiocarcinoma (DCC) regarding recurrence and the factors that...
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Approach to Resectable Biliary Cancers
Biliary malignancies, although rare, can be some of the most challenging to manage surgically. Intrahepatic cholangiocarcinomas are resectable if...
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Intraductal papillary neoplasm of the bile duct with metachronous development in the downstream bile duct after radical resection
We report a case of intraductal papillary neoplasms of the bile duct (IPNB) that metachronously developed twice in the downstream bile duct after...
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Postoperative Prognosis According to Pathologic Categorization of Desmoplastic Reaction in Patients with Extrahepatic Cholangiocarcinoma
BackgroundRecent studies have demonstrated the importance of desmoplastic reaction (DR) in predicting postoperative prognosis for patients with...
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Applications of artificial intelligence in biliary tract cancers
Biliary tract cancers are malignant neoplasms arising from bile duct epithelial cells. They include cholangiocarcinomas and gallbladder cancer....
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Albumin, filamin-A and cytokeratin 19 help distinguish intrahepatic cholangiocarcinoma from extrahepatic adenocarcinoma
BackgroundThe differential diagnosis of intrahepatic cholangiocarcinomas (iCCAs) from metastatic adenocarcinomas from organs adjacent to the liver...
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Immunotherapy in Biliary Tract Cancers: Where Are We?
Purpose of ReviewBiliary tract cancers (BTCs) are a heterogenous group of cancers arising from the biliary tract. The hallmark of these cancers is...
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Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma
The mutant IDH1 inhibitor ivosidenib improves outcomes for patients with IDH1- mutated cholangiocarcinoma, but resistance inevitably develops....
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CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas
ObjectivesTo identify imaging features that assist in discriminating intraductal papillary neoplasms of the bile duct (IPNBs) from papillary...
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Testing for ROS1, ALK, MET, and HER2 rearrangements and amplifications in a large series of biliary tract adenocarcinomas
Biliary tract carcinomas are divided into intrahepatic, perihilar, distal extrahepatic cholangiocarcinomas, and gallbladder adenocarcinomas....
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Rolle der Resektion und Transplantation beim Cholangiokarzinom
Surgical resection represents the backbone of a curative therapeutic approach for cholangiocarcinomas. Precise understanding of the individual...
