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Chemotherapy periodization to maximize resistance training adaptations in oncology
IntroductionEngaging in exercise programs during cancer treatment is challenging due to the several chemotherapy-induced side effects. Using a...
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Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen
PurposeTo explore the potential of circRNAs as biomarkers in non-invasive body fluids for monitoring chemotherapy resistance in SCLC patients.
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Chemotherapy versus personalized therapy for EGFR mutant lung adenocarcinoma resistance to EGFR-tyrosine kinase inhibitors: a retrospective dual-center study
BackgroundAdvanced lung adenocarcinoma patients often develop resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs), leaving uncertainties...
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Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia
Chemotherapy-resistant acute myeloid leukemia (AML), frequently driven by clonal evolution, has a dismal prognosis. A genome-wide CRISPR knockout...
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M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits its curative effect. Here,...
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Patient-Derived Organoids from Locally Advanced Gastric Adenocarcinomas Can Predict Resistance to Neoadjuvant Chemotherapy
BackgroundPatients (pts) with locally advanced gastric adenocarcinoma (LAGA) often receive neoadjuvant chemotherapy. A minority of patients do not...
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Targeting cancer stem cells as a strategy for reducing chemotherapy resistance in head and neck cancers
PurposeResistance to chemotherapy and radiotherapy is the primary cause of a poor prognosis in oncological patients. Researchers identified many...
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Prognostic Factors Associated with hCG Remission and Chemotherapy Resistance in Patients with High-Risk Gestational Trophoblastic Neoplasia
ObjectiveThe main aim of this study was to assess the effect of various clinical factors on time to hCG remission and chemoresistance among women...
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Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
The patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL) have poor prognosis, and a novel and effective therapeutic strategy...
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Albumin/fibrinogen ratio, a predictor of chemotherapy resistance and prognostic factor for advanced gastric cancer patients following radical gastrectomy
BackgroundThe objective of this study was to investigate potential predictors of chemotherapy resistance in patients with advanced gastric cancer...
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Real-World Data About Treatment Outcomes for Patients with EGFR-Mutated NSCLC Resistance to Osimertinib and Platinum-Based Chemotherapy
IntroductionDocetaxel is an established standard therapy after osimertinib and platinum-based doublet chemotherapy (Pt-doublet) for locally advanced...
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Angiogenesis and chemotherapy resistance: optimizing chemotherapy scheduling using mathematical modeling
Chemotherapy remains a widely used cancer treatment. Acquired drug resistance may greatly reduce the efficacy of treatment and means to overcome it...
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Deep learning predicts resistance to neoadjuvant chemotherapy for locally advanced gastric cancer: a multicenter study
BackgroundAccurate pre-treatment prediction of neoadjuvant chemotherapy (NACT) resistance in patients with locally advanced gastric cancer (LAGC) is...
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Short-term effects of a new resistance exercise approach on physical function during chemotherapy after radical breast cancer surgery: a randomized controlled trial
BackgroundApproximately 30% of post-operative breast cancer patients develop shoulder joint movement disorders affecting routine upper limb movement....
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m6A regulators as predictive biomarkers for chemotherapy benefit and potential therapeutic targets for overcoming chemotherapy resistance in small-cell lung cancer
Small-cell lung cancer (SCLC) is a devastating subtype of lung cancer with few therapeutic options. Despite the advent of immunotherapy,...
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Intermittent fasting during adjuvant chemotherapy may promote differential stress resistance in breast cancer patients
BackgroundPreclinical studies prove that short-term fasting secures healthy cells against chemotherapy side effects and makes malignant cells more...
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Urachal mixed adenocarcinoma and small cell neuroendocrine carcinoma with widespread metastasis and resistance to chemotherapy: a case report
Neuroendocrine carcinoma arising from the urachus is extremely rare. We describe a case of a 33-year-old gentleman who presented with hematuria and...
