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Immune-related LncRNAs scores predicts chemotherapeutic responses and prognosis in cervical cancer patients
BackgroundLong non-coding RNAs (LncRNAs) regulating the immune microenvironment of cancer is a hot spot. But little is known about the influence of...
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Role of natural P-gp inhibitor in the effective delivery for chemotherapeutic agents
Multi-drug resistance has shown to be one of the leading threats faced currently in many chemotherapeutic agents. Permeability glycoprotein (P-gp) is...
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Sub-lethal doses of chemotherapeutic agents induce senescence in T cells and upregulation of PD-1 expression
Cellular senescence is a stable cell cycle arrest, usually in response to internal and/or external stress, including telomere dysfunction, abnormal...
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Comparative Analysis of Cell Senescence Induced by the Chemotherapeutic Agents Doxorubicin, Cisplatin and Arsenic Trioxide in Human Myoblasts MB135
AbstractGenotoxic and cytotoxic drugs, widely used in anticancer therapy, target proliferating cells and induce cell death through a variety of cell...
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Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling
Conventional chemotherapy targets malignant cells without evaluating counter protection from the tumor microenvironment that often causes treatment...
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Impact of Chemotherapeutic Agents on PD-L1, CTLA-4, and VISTA Gene Expression in Cervical Cancer Cell Lines: An In Vitro Study
PurposeThe study aims to understand how docetaxel and doxorubicin, two commonly used chemotherapeutic drugs, influence the expression of PD-L1,...
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Inhibition of FEN1 promotes DNA damage and enhances chemotherapeutic response in prostate cancer cells
Prostate cancer (PCa) refers to epithelial malignancies occurring in prostate and is the most commonly diagnosed cancer among men. Flap...
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TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity
The heterogeneity and drug resistance of colorectal cancer (CRC) often lead to treatment failure. Isocitrate dehydrogenase 1 (IDH1), a rate-limiting...
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The effects of chemotherapeutic drugs on PD-L1 gene expression in breast cancer cell lines
Breast cancer is the most common cancer among women in terms of prevalence and mortality, and chemotherapy is one of the most effective treatments at...
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Toxic leukoencephalopathy with axonal spheroids caused by chemotherapeutic drugs other than methotrexate
BackgroundThe objective of this report is to share the clinicopathological features of chemotherapy-induced toxic leukoencephalopathy, which is a...
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Establishing the applicability of cancer vaccines in combination with chemotherapeutic entities: current aspect and achievable prospects
Cancer immunotherapy is one of the recently developed cancer treatment modalities. When compared with conventional anticancer drug regimens,...
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A Prospective Study on Metronomic Scheduling of Non-chemotherapeutic Drugs in Advanced Epithelial Ovarian Cancers
The objectives of this study are to assess the role of non-chemotherapeutic combination of drugs as maintenance therapy, after standard treatment,...
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USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer
Ubiquitin-specific-processing proteases 35 (USP35) is an under-characterized deubiquitinase and its role in colorectal cancer (CRC) remains unclear....
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Fanconi anemia complementation group D2 promotes sensitivity of endometrial cancer cells to chemotherapeutic agents by inhibiting the ferroptosis pathway
BackgroundResistance can develop during treatment of advanced endometrial cancer (EC), leading to unsatisfactory results. Fanconi anemia...
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Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma
ObjectiveOvarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian cancer. The prognosis of advanced and recurrent disease is...
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Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Cancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late...
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Is switching intravesical chemotherapeutic agents beneficial in short-term recurrent high-risk non-muscle-invasive bladder tumors? A 5-year retrospective study
ObjectiveTo explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive...
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Comparison of the immunomodulatory potential of platinum-based anti-cancer drugs and anthracyclins on human monocyte-derived cells
Macrophages and dendritic cells (DCs) are important contributors to anti-tumor immune responses. However, these highly plastic cells are also the...
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D,L-Methadone enhances the cytotoxic activity of standard chemotherapeutic agents on pediatric rhabdomyosarcoma
PurposeIn advanced tumor stages, pediatric rhabdomyosarcoma (RMS) shows an intrinsic resistance to standard chemotherapy, which is associated with a...
