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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a ‘highly transmissible respiratory pathogen, leading to severe multi-organ damage....
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The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health
Recent research demonstrates a reciprocal relationship between gut microbiota-derived metabolites and the host in controlling the energy homeostasis...
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White adipose tissue mitochondrial bioenergetics in metabolic diseases
White adipose tissue (WAT) is an important endocrine organ that regulates systemic energy metabolism. In metabolically unhealthy obesity, adipocytes...
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Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver Disease
Purpose of the ReviewMitochondrial dysfunction has long been proposed to play a crucial role in the pathogenesis of a considerable number of...
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The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation
Bromodomain containing 1 ( BRD1) encodes an epigenetic regulator that controls the expression of genetic networks linked to mental illness. BRD1 is...
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Ozone high dose therapy (OHT) improves mitochondrial bioenergetics in peripheral blood mononuclear cells
BackgroundThe worldwide increasing number of people with chronic diseases is pushing conventional therapy to its limits. The so-called Major...
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Empagliflozin does not reverse lipotoxicity-induced impairment in human myeloid angiogenic cell bioenergetics
BackgroundEmpagliflozin can curb inflammation and oxidative stress, through sodium-proton exchanger (NHE) inhibition, in a model of lipotoxicity in...
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A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres
PurposeGlioblastoma (GBM) is a rapidly growing tumor in the central nervous system with altered metabolism. Depleting the bioenergetics of tumors...
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Bioenergetics of photobiomodulated osteoblast mitochondrial cells derived from human pulp stem cells: systematic review
Dental pulp cells are a source of multipotent mesenchymal stem cells with a high proliferation rate and multilineage differentiation potential. This...
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Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties
The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that...
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Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder
Neurodevelopmental regression (NDR) is a subtype of autism spectrum disorder (ASD) that manifests as loss of previously acquired developmental...
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Enhanced bioenergetic cellular activity with metabolic switch to aerobic glycolysis in Keloid and Folliculitis Keloidalis Nuchae
Keloid scars and folliculitis keloidalis nuchae (FKN) are benign fibroproliferative dermal lesions of unknown aetiology and ill-defined treatment,...
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UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases
BackgroundMitochondrial diseases represent one of the most common groups of genetic diseases. With a prevalence greater than 1 in 5000 adults, such...
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Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis
Recent studies have shown that cellular levels of polyamines (PAs) are significantly altered in neurodegenerative diseases. Evidence from in vivo ...
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Schizophrenia: a disorder of broken brain bioenergetics
A substantial and diverse body of literature suggests that the pathophysiology of schizophrenia is related to deficits of bioenergetic function....
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Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis
The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized by excessive deposition of extracellular matrix...
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RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly...
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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition to deteriorated disorders....
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Modulation of Mitochondrial Function as a Therapeutic Strategy for Neurodegenerative Diseases
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer’s Disease, strategies that target early molecular mechanisms and could delay or...
