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Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids
Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the manifestation of psychiatric symptoms in early adulthood. While...
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Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies
Lenalidomide is a synthetic analog of thalidomide formed by the removal of one keto group (plus the addition of an amino group); it has anti-tumor...
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Capillary leak and endothelial permeability in critically ill patients: a current overview
Capillary leak syndrome (CLS) represents a phenotype of increased fluid extravasation, resulting in intravascular hypovolemia, extravascular edema...
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The relationship between peritoneal membrane permeability and dyspepsia in peritoneal dialysis patients
ObjectiveThe aim of this study is to determine whether there is a relationship between peritoneal membrane permeability and dyspepsia in peritoneal...
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Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
Purpose of the ReviewTo review what intestinal permeability is and how it is measured, and to summarise the current evidence linking altered...
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Paracellular permeability and tight junction regulation in gut health and disease
Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight junctions via two distinct...
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Chlorogenic acid-optimized nanophytovesicles: a novel approach for enhanced permeability and oral bioavailability
BackgroundChlorogenic acid, a phenolic derivative, shows excellent pharmacological properties. However, poor lipidic solubility, permeability, and...
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Semaphorin 7A promotes endothelial permeability and inflammation via plexin C1 and integrin β1 in Kawasaki disease
BackgroundKawasaki disease (KD) is a pediatric systemic vasculitis characterized by endothelial cell dysfunction. Semaphorin 7A (Sema7A) has been...
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Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability,...
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Genes modulating intestinal permeability and microbial community are dysregulated in sickle cell disease
Based on previous studies showing abnormalities in the intestinal pathophysiology characterized by disruption in the gut barrier functions, and...
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Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
BackgroundIn acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics....
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Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials
BackgroundIncreasing intestinal permeability causes chronic inflammation, which is one of the etiological factors of many diseases that presently...
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Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability
As the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor...
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TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination
BackgroundDiabetic retinopathy (DR) as a severe diabetic complication contributes to blindness. The increased permeability of retinal capillary...
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The glycocalyx as a permeability barrier: basic science and clinical evidence
Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability...
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Ameliorative Effects of Larazotide Acetate on Intestinal Permeability and Bacterial Translocation in Acute Pancreatitis Model in Rats
BackgroundIntestinal barrier dysfunction in acute pancreatitis (AP) may progress to systemic inflammatory response syndrome (SIRS) and multi-organ...
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Effects of hydrophilic polymer-embedded membrane on permeability and cell adhesion during continuous hemofiltration
Background and AimsClotting within the membrane and/or venous ‘air trap’ chamber is common problems during continuous blood purification therapy....
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Intestinal permeability in patients with IgA nephropathy and other glomerular diseases: an observational study
BackgroundA dysregulated ‘gut-kidney axis’ may contribute to immunoglobulin A nephropathy (IgAN). We studied whether IgAN patients have disturbed...
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The effect of an acute aspirin challenge on intestinal permeability in healthy adults with and without prophylactic probiotic consumption: a double-blind, placebo-controlled, randomized trial
BackgroundHealthy individuals may experience increases in intestinal permeability after chronic or acute use of non-steroidal anti-inflammatory...
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Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis
BackgroundIntestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with...
