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Targeting cardiomyocyte cell cycle regulation in heart failure
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult...
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Regulation of Cardiomyocyte Division During Cardiac Regeneration
Purpose of ReviewThis review explores efforts made over the previous three decades to determine mechanisms of cardiomyocyte cell division. Many...
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Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy
BackgroundPhysiological and pathological cardiomyocyte hypertrophy are important pathophysiological processes of adult congenital heart...
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Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeutics are mainly symptomatic...
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Catecholamine treatment induces reversible heart injury and cardiomyocyte gene expression
BackgroundCatecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock....
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The molecular mechanism of MiR-26a-5p regulates autophagy and activates NLRP3 inflammasome to mediate cardiomyocyte hypertrophy
ObjectiveMany studies have found that miR-26a-5p plays an essential role in the progression of pathological cardiac hypertrophy, however, there is...
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Quantification of Cardiomyocyte Contraction In Vitro and Drug Screening by MyocytoBeats
Cardiomyocyte contractility is the crucial feature of heart function. Quantifying cardiomyocyte contraction in vitro is essential for disease...
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Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway
BackgroundHypoxia/reoxygenation (H/R)-induced cardiomyocyte cell apoptosis is critical in develo** myocardial infarction. Stachydrine (STA), an...
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Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction
BackgroundThe activation of G protein-coupled receptors (GPCR) signaling by external stimuli has been implicated in inducing cardiac stress and...
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miR-30a-5p attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by regulating PTEN protein expression and activating PI3K/Akt signaling pathway
BackgroundThis study was designed to investigate the mechanism by which miR-30a-5p mediates cardiomyocyte apoptosis after acute myocardial infarction...
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HOTAIR regulates SIRT3-mediated cardiomyocyte survival after myocardial ischemia/reperfusion by interacting with FUS
BackgroundMyocardial ischemia/reperfusion (I/R) contributes to serious myocardial injury and even death. Therefore, prevention and mitigation of...
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Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and impedes its contractile...
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Dexmedetomidine ameliorates x-ray-induced myocardial injury via alleviating cardiomyocyte apoptosis and autophagy
BackgroundRadiotherapy is a primary local treatment for tumors, yet it may lead to complications such as radiation-induced heart disease (RIHD)....
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Selenium nanoparticles reduce oxidative stress-induced cardiomyocyte apoptosis in ascites syndrome in broiler chickens via the ATF6-DR5 signaling pathway
Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well documented that myocardial hypertrophy and...
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Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice
Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating diabetic cardiomyopathy (DCM) but has been found to be a substrate of a...
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Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits
ObjectiveCymbopogon citratus (DC.) Stapf is a medicinal and edible herb that is widely used for the treatment of gastric, nervous and hypertensive...
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Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation
During embryonic development, cardiomyocytes undergo differentiation and maturation, processes that are tightly regulated by tissue-specific...
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Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation
BackgroundDiabetic cardiomyopathy (DCM) is a crucial complication of long-term chronic diabetes that can lead to myocardial hypertrophy, myocardial...
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Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT
BackgroundDoxorubicin (DOX) has limited chemotherapy application for malignancies due to cardiotoxicity. The pathogenesis of DOX-induced...
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Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways
BackgroundAllicin is a bioactive compound with potent antioxidative activity and plays a protective effect in myocardial damage and fibrosis. The...
