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Delivery of SIRT1 by cancer-associated adipocyte-derived extracellular vesicles regulates immune response and tumorigenesis of ovarian cancer cells
PurposeThis study intends to investigate the possible molecular mechanism of immune response and tumorigenesis in ovarian cancer cells, mediated by...
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Adipocyte-derived extracellular vesicles: bridging the communications between obesity and tumor microenvironment
By the year 2035 more than 4 billion people might be affected by obesity and being overweight. Adipocyte-derived Extracellular Vesicles...
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SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation
BackgroundIn obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number...
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Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum....
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20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology
20 years ago, we described a human cell strain derived from subcutaneous adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome...
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Adipose tissue macrophages: implications for obesity-associated cancer
Obesity is one of the most serious global health problems, with an incidence that increases yearly and coincides with the development of cancer....
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Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss
Purpose of ReviewBeyond aging, senescent cells accumulate during multiple pathological conditions, including chemotherapy, radiation,...
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Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood, a discovery analysis
BackgroundMaternal body size, nutrition, and hyperglycemia contribute to neonatal body size and composition. There is little information on...
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Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor–adipocyte interaction indicating an altered immune response
BackgroundRecently, we presented Stroma AReactive Invasion Front Areas (SARIFA) as a new histomorphologic negative prognostic biomarker in gastric...
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Targeting adipocyte–immune cell crosstalk to control breast cancer progression
Adipocytes are crucial components of breast cancer and are involved in regulating the progression, therapeutic efficacy, and prognosis of breast...
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Cancer-associated fibroblasts: heterogeneity and their role in the tumor immune response
In recent decades, many reports have been published on the composition and function of the tumor microenvironment (TME), among which...
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Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation
ObjectivesMetabolic inflammation is a hallmark of obesity and related disorders, afflicting substantial morbidity and mortality to individuals...
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LINC01119 encapsulated by cancer-associated adipocytes-derived exosomes promotes M2 polarization of macrophages to induce immune escape in ovarian cancer in a 3D co-culture cell-based model
IntroductionIn the present study, we sought to clarify the role of LINC01119 delivered by cancer-associated adipocytes (CAAs)-derived exosomes...
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Heterogeneity and interplay: the multifaceted role of cancer-associated fibroblasts in the tumor and therapeutic strategies
The journey of cancer development is a multifaceted and staged process. The array of treatments available for cancer varies significantly, dictated...
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Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity
BackgroundThe timing of obesity onset and age have been shown to affect the risk of obesity-related comorbidities, although the impact of each of...
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Obesity-associated epigenetic alterations and the obesity-breast cancer axis
Both breast cancer and obesity can regulate epigenetic changes or be regulated by epigenetic changes. Due to the well-established link between...
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The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling
Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between...
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Stratification and prognostic evaluation of breast cancer subtypes defined by obesity-associated genes
ObjectiveBreast cancer was the most common type of cancer among women worldwide, significantly impacting their quality of life and survival rates....
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Tianhuang formula regulates adipocyte mitochondrial function by AMPK/MICU1 pathway in HFD/STZ-induced T2DM mice
BackgroundTianhuang formula (THF) is a Chinese medicine prescription that is patented and clinically approved, and has been shown to improve energy...
