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1. San** Paishi Decoction improves the imbalance of gut microbiota and regulates MAPK signaling pathway to inhibit calcium oxalate stones in rats

   Introduction

   San** Paishi Decoction (SJPSD) has positive effects on stone prevention; however, there is a lack of convincing evidence in the...

   Ying Tian, Juan Zhao, ... Yuguo **a in International Urology and Nephrology

   Article 27 June 2023
   

2. Astroglial calcium signaling and homeostasis in tuberous sclerosis complex

   Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in various organs, including the...

   Alessia Romagnolo, Giulia Dematteis, ... Eleonora Aronica in Acta Neuropathologica

   Article Open access 28 February 2024
   

3. Notch signaling pathway: a new target for neuropathic pain therapy

   The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the...

   Yan Zhang, Tingting Wang, ... Yan Zhang in The Journal of Headache and Pain

   Article Open access 15 July 2023
   

4. NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma

   Although several types of calcium channels abnormalities have been shown to promote myeloma bone disease (MBD), the relationship between Na ⁺ /Ca ²⁺ exch...

   Tingting Li, Dongbiao Qiu, ... Zhiyong Zeng in Clinical and Experimental Medicine

   Article Open access 17 October 2022
   

5. Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation

   Background

   Microcystic adnexal carcinoma (MAC) is a skin cancer with challenges in diagnosis and management. This study was aimed to detect molecular...

   Shuaixia Yu, Yang Wang, ... Huajun Sun in World Journal of Surgical Oncology

   Article Open access 04 May 2022
   

6. Klotho inhibits the formation of calcium oxalate stones by regulating the Keap1-Nrf2-ARE signaling pathway

   Purpose

   Oxidative damage is important in calcium oxalate (CaOx) stone development but occurs via multiple pathways. Studies have shown that klotho...

   Bahtiyar Ahmatjan, Liu ruotian, ... Murat Mahmut in International Urology and Nephrology

   Article 07 November 2022
   

7. Puerarin prevents calcium oxalate crystal-induced renal epithelial cell autophagy by activating the SIRT1-mediated signaling pathway

   Calcium oxalate (CaOx) crystals can activate autophagy, causing damage to renal tubular epithelial cells (TECs). Puerarin has been shown to have...

   Guan-Hua **g, Ya-Dong Liu, ... Rui-Hua An in Urolithiasis

   Article 01 August 2022
   

8. Natural products targeting the MAPK-signaling pathway in cancer: overview

   Purpose

   This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures,...

   Aiwen Shi, Li Liu, ... Bin Qi in Journal of Cancer Research and Clinical Oncology

   Article Open access 09 January 2024
   

9. Calcium sensing and signaling are impaired in the lumbar spine of a rat model of congenital kyphosis

   Purpose

   Kyphosis involves spines curving excessively backward beyond their physiological curvature. Although the normal structure of the spinal...

   Itsuki Takahashi, Yusuke Watanabe, ... Noriaki Shimokawa in European Spine Journal

   Article 09 August 2023
   

10. NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway

    Melanoma is the most aggressive cutaneous tumor. Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis. However, the functional...

    Susi Zhu, Xu Zhang, ... Cong Peng in Frontiers of Medicine

    Article 04 February 2023

11. RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin

    The effect of Ryanodine receptor2 (RyR2) and its stabilizer on cardiac hypertrophy is not well known. C57/BL6 mice underwent transverse aortic...

    Yi Gao, Shuai Li, ... ** Yang in Journal of Cardiovascular Translational Research

    Article 23 April 2024
    

12. Exploring the effects of Hippo signaling pathway on rumen epithelial proliferation

    Background

    The current understanding to the mechanism of rumen development is limited. We hypothesized that the Hippo signaling pathway controlled the...

    Bin Yang, Zebang Xu, ... Jiakun Wang in BMC Veterinary Research

    Article Open access 10 May 2024
    

13. Quercetin Attenuates Atherosclerosis via Modulating Apelin Signaling Pathway Based on Plasma Metabolomics

    Objective

    To interpret the pharmacology of quercetin in treatment of atherosclerosis (AS).

    Methods

    Fourteen apolipoprotein E-deficient (ApoE ^−/− ) mice...

    Li-qun Liu, Peng Zhang, ... Chuan-hua Yang in Chinese Journal of Integrative Medicine

    Article 01 September 2023

14. Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury

    Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion...

    Chang-xing Liu, **n-yi Guo, ... He Wang in Chinese Journal of Integrative Medicine

    Article 08 February 2024

15. Wilforine inhibits rheumatoid arthritis pathology through the Wnt11/β-catenin signaling pathway axis

    Background

    Wilforine (WFR) is a monomeric compound of the anti-RA plant Tripterygium wilfordii Hook. f. (TwHF). Whether WFR has anti-RA effect, its...

    Yurong Huang, Yanhui Peng, ... Chenggui Miao in Arthritis Research & Therapy

    Article Open access 14 December 2023
    

16. Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

    Objective and background

    The deficiency of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) causes the phenotype similar to knee...

    Zhiqiang Gao, Qiang Wang, ... Yufeng Huang in Journal of Orthopaedic Surgery and Research

    Article Open access 27 June 2023
    

17. mir-150-5p inhibits the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by targeting irisin to regulate the p38/MAPK signaling pathway

    Purpose

    To study the effect of miR-150-5p on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), and further explore...

    Jia-long Qi, Zhi-dong Zhang, ... Zong-sheng Yin in Journal of Orthopaedic Surgery and Research

    Article Open access 18 March 2024
    

18. MicroRNA-204 attenuates oxidative stress damage of renal tubular epithelial cells in calcium oxalate kidney-stone formation via MUC4-mediated ERK signaling pathway

    Oxalate-induced oxidative stress causes damage to cells, accompanied with renal deposition of calcium oxalate crystals. Recent studies have...

    Zhijuan **e, Jianying Chen, Zhong Chen in Urolithiasis

    Article 16 November 2021
    

19. Single-cell RNA-seq analysis reveals the Wnt/Ca²⁺ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

    Background

    Increasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc...

    Peigeng Wang, Zhencong Li, Dong** Ye in BMC Musculoskeletal Disorders

    Article Open access 23 April 2024
    

20. Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway

    The process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM) has significant...

    Hongjuan Cao, Lina Zhao, ... Bei Zhang in Journal of Cardiovascular Translational Research

    Article Open access 09 February 2024