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Pre-conceptional paternal diet impacts on offspring testosterone homoeostasis via epigenetic modulation of cyp19a1/aromatase activity
Paternal eating habits, before and at conception, have a strong impact on offspring future metabolism. By sending specific epigenetic signals through...
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Association of CYP19A1 rs28757157 polymorphism with lung cancer risk in the Chinese Han population
BackgroundLung cancer is the leading cause of cancer death globally. Recent studies have revealed that CYP19A1 gene plays a crucial role in cancer...
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Administration of metformin ameliorates endocrine abnormalities associated with mouse model of PCOS by increasing Cyp19a1 expression
A number of reproductive aged women often suffer from polycystic ovarian syndrome (PCOS). This study attempted to determine how metformin affects the...
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Association between single nucleotide polymorphism of the CYP19A1 and ESR2 genes and endometriosis
PurposeEndometriosis is a frequent gynaecological condition, both in Poland and in the world. The development of this disease is supported by...
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Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice
PurposeAromatase plays an important role in ovarian development, the normal progress of the menstrual cycle, and fertility status. Elevated aromatase...
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Association of CYP19A1 gene variations with adjuvant letrozole-induced adverse events in South Indian postmenopausal breast cancer cohort expressing hormone-receptor positivity
PurposeMusculoskeletal adverse events (MS-AEs) and vasomotor symptoms (VMSs) are the major side-effects of newer generation non-steroidal aromatase...
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Advanced Glycation End-Products of Follicular Fluid are Associated with Embryo Morphokinetic Parameters and ART Outcomes
Advanced glycation end products (AGEs) can disrupt antioxidant system and steroidogenesis, resulting in detrimental effects on assisted reproductive...
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Orexin antagonism and substance-P: Effects and interactions on polycystic ovary syndrome in the wistar rats
BackgroundPolycystic ovary syndrome (PCOS) is a prevalent endocrine disorder without definitive treatments. Orexin and Substance-P (SP) neuropeptides...
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Steroidogenic activity of liposomal methylated resveratrol analog 3,4,5,4′-tetramethoxystilbene (DMU-212) in human luteinized granulosa cells in a primary three-dimensional in vitro model
PurposeSteroid hormone secretion is one of the key functions of granulosa cells (GCs). Resveratrol is a natural polyphenol, known for its beneficial...
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Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy
PurposeThe aim of this study was to conduct an association analysis of depressive symptoms and polymorphisms in the ESR1 , PGR , CYP19A1, and COMT ...
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In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC
The Fucaceae family of marine brown algae includes Ascophyllum nodosum. Fucosterol (FSL) is a unique bioactive component that was identified through...
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Dysregulation of intraovarian redox status and steroidogenesis pathway in letrozole-induced PCOS rat model: a possible modulatory role of l-Carnitine
BackgroundPolycystic ovarian syndrome (PCOS) is a reproductive disorder associated with several endocrine and metabolic alterations. The mechanism...
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Paternal genetic effects of cadmium exposure during pregnancy on hormone synthesis disorders in ovarian granulosa cells of offspring
The aim of this study was to investigate the paternal genetic intergenerational and transgenerational genetic effects of cadmium (Cd) exposure during...
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Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene
PurposeTo evaluate the influence of single nucleotide polymorphisms (SNPs) of CYP19A1 on the response and susceptibility to side effects from...
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Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model
BackgroundIndustrial progress has led to the omnipresence of chemicals in the environment of the general population, including reproductive-aged and...
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Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review
BackgroundMammography Density (MD) is a potential risk marker that is influenced by genetic polymorphisms and can subsequently modulate the risk of...
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Investigating the potential role of swertiamarin on insulin resistant and non-insulin resistant granulosa cells of poly cystic ovarian syndrome patients
Background and aimConventional drugs have limitations due to prevalence of contraindications in PCOS patients. To explore the potential effects of...
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The profile of steroid hormones in human fetal and adult ovaries
BackgroundReproduction in women is at risk due to exposure to chemicals that can disrupt the endocrine system during different windows of sensitivity...
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Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis
BackgroundZishen Yutai (ZSYT) pill, a patent Chinese medicine, has been widely used in the treatment of infertility, abortion, and adjunctive...
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The impact of genetic polymorphism on CYP19A1 in androgen-deprivation therapy among Japanese men
PurposeInadequate suppression of testosterone during androgen-deprivation therapy impairs its efficacy. This study investigated the significance of...
