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Whole lung lavage and GM-CSF use for pulmonary alveolar proteinosis in an infant with lysinuric protein intolerance: a case report
BackgroundLysinuric protein intolerance (LPI) is a multi-organ metabolic disorder characterized by the imbalance in absorption and excretion of...
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CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review
BackgroundThe molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) remain elusive. The aim of this systematic review...
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Chitinase-3-like 1-protein in CSF: a novel biomarker for progression in patients with multiple sclerosis
BackgroundChitinase -3-like 1-protein (CHI3L1) is a glycoside secreted by monocytes, microglia, and activated astrocytes. Its distribution in...
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CSF shunt valve occlusion—does CSF protein and cell count matter?
BackgroundShunt obstruction is a common cause of shunt failure in the treatment of hydrocephalus. Valve occlusion is traditionally believed to...
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Clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma
The clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma (ND-DLBCL) remains largely unexplored. One...
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Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer’s disease
Β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) is a crucial protease in the production of amyloid-β (Aβ) in Alzheimer’s disease (AD)...
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Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus
BackgroundBy applying an unbiased proteomic approach, we aimed to search for cerebrospinal fluid (CSF) protein biomarkers distinguishing between...
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PCR-positive meningococcal CSF infection without pleocytosis but high IL-6 and IL-8
BackgroundMeningococcal meningitis is still a severe disease causing high mortality and morbidity rates. Early diagnosis is crucial to ensure prompt...
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Severe CSF immune cell alterations in cryptococcal meningitis gradually resolve during antifungal therapy
Cryptococcal meningitis (CM) is a severe fungal disease in immunocompromised patients affecting the central nervous system (CNS). Host response and...
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Is blood pTau a reliable indicator of the CSF status? A narrative review
BackgroundThe identification of biomarkers for the early diagnosis of Alzheimer’s disease (AD) is a crucial goal of the current research. Blood...
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Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling
BackgroundNeuropsychiatric systemic lupus erythematosus (NPSLE), with various morbidities and multiple manifestations in the central nervous system,...
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Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer’s disease
Alzheimer’s disease (AD) is influenced by a variety of modifiable risk factors, including a person’s dietary habits. While the ketogenic diet (KD)...
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CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease
Post-mortem staging of Alzheimer’s disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for...
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Trans-Nasal Endoscopic Repair of CSF Rhinorrhea: An Institutional Experience
IntroductionCerebrospinal Fluid (CSF) rhinorrhea results from breakdown in the integrity of structures separating the subarachnoid space and nasal...
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Neurodegeneration or dysfunction in Phelan-McDermid syndrome? A multimodal approach with CSF and computational MRI
BackgroundPhelan-McDermid syndrome (PMS) is a rare multisystem disease with global developmental delay and autistic features. Genetically, the...
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Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review
Corticobasal syndrome (CBS) is a clinical syndrome determined by various underlying neurodegenerative disorders requiring a pathological assessment...
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Temporal Changes in CSF Cell Parameters After SAH: Comparison of Ventricular and Spinal Drain Samples
BackgroundForty percent of patients with aneurysmatic subarachnoid hemorrhage (aSAH) develop acute hydrocephalus requiring treatment with...
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Dynamic changes of CSF clusterin levels across the Alzheimer’s disease continuum
BackgroundClusterin is a multifunctional protein, which is associated with the pathogenesis and the development of Alzheimer’s disease (AD). Compared...
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Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular...
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Bile acid profile associated with CSF and PET biomarkers in Alzheimer’s disease
BackgroundRecent studies have shown that gut microbiota can affect the development of Alzheimer’s disease (AD) through various mechanisms. Bile acids...
