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Real-time, random-access organ screening for carbapenem-resistant organisms (CRO) reduces CRO-associated, donor-derived infection mortality in lung transplant recipients
PurposeDonor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus...
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Impact of Immunosuppressed Status on Prognosis of Carbapenem-Resistant Organisms Bloodstream Infections
IntroductionThe impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim...
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Clinical Efficacy and Safety of Colistin Sulfate in the Treatment of Carbapenem-Resistant Organism Infections in Patients with Hematological Diseases
IntroductionCarbapenem-resistant organisms (CRO) have emerged as a significant worldwide issue. However, the availability of efficacious antibiotics...
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The impact of aerobic exercise training and crocin consumption on MuRf-1 level in skeletal muscle in high-fat fed ovariectomized rat models
Estrogen deficiency intensifies sarcopenia by activation of inflammatory and oxidative pathways. Aerobic exercise training and...
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Optimization of polymyxin B regimens for the treatment of carbapenem-resistant organism nosocomial pneumonia: a real-world prospective study
BackgroundPolymyxin B is the first-line therapy for Carbapenem-resistant organism (CRO) nosocomial pneumonia. However, clinical data for its...
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Risk Factors for Mortality Among Critical Acute Pancreatitis Patients with Carbapenem-Resistant Organism Infections and Drug Resistance of Causative Pathogens
IntroductionCarbapenem-resistant organisms (CRO) have emerged as a major global public health threat, but their role in critical acute pancreatitis...
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Drug Resistance and Risk Factors for Acquisition of Gram-Negative Bacteria and Carbapenem-Resistant Organisms Among Liver Transplant Recipients
IntroductionInfections caused by Gram-negative bacteria, in particular carbapenem-resistant organisms (CRO), pose a great threat to liver transplant...
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Multicenter Study on COVID-19 Lung Computed Tomography Segmentation with varying Glass Ground Opacities using Unseen Deep Learning Artificial Intelligence Paradigms: COVLIAS 1.0 Validation
Variations in COVID-19 lesions such as glass ground opacities (GGO), consolidations, and crazy paving can compromise the ability of solo-deep...
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Efficacy and safety of polymyxin B in carbapenem-resistant gram-negative organisms infections
ObjectiveTo investigate how to use polymyxin B rationally in order to produce the best efficacy and safety in patients with carbapenem-resistant...
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Croatian version of the neck disability index can distinguish between acute, chronic and no neck pain
ObjectiveLongitudinal study to test the validity and reliability of the Croatian version of the neck disability index (NDI-CRO) for use in patients.
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Zusammenarbeit mit klinischen Auftragsforschungsinstituten
Clinical trials with pharmaceuticals or medical devices make complex demands on sponsors and participating centers. During the past two decades,...
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Current Practices and Challenges When Submitting Patient Experience Data for Regulatory Decisions by the US Food and Drug Administration: An Industry Survey
ObjectivesTo understand industry practices and challenges when submitting patient experience data (PED) for regulatory decisions by the US Food and...
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Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy
BackgroundMeningococcal meningitis (MM) is a life-threatening disease associated with approximately 10% case fatality rates and neurological sequelae...
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Does social participation decrease the risk of frailty? Impacts of diversity in frequency and types of social participation on frailty in middle-aged and older populations
BackgroundSocial participation (SP) may be an effective measure for decreasing frailty risks. This study investigated whether frequency and type of...
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Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2
A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral...
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Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection
ObjectivesChlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are the commonest bacterial causes of sexually transmitted infections in humans...
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Peer review program to enhance treatment planning quality assurance for community radiation oncologists
ObjectiveMany cancer patients are treated at treatment centers staffed by community radiation oncologists (CRO). Patients choose these facilities for...
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Carbapenem-resistant gram-negative bacterial infections and risk factors for acquisition in a Kenyan intensive care unit
BackgroundCarbapenem-resistant Gram-negative bacteria (CR-GNB) are a critical public health threat globally; however, there are inadequate...
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1g versus 2 g daily intravenous ceftriaxone in the treatment of community onset pneumonia – a propensity score analysis of data from a Japanese multicenter registry
BackgroundCommunity-onset pneumonia (COP) is a combined concept of community acquired pneumonia and the previous classification of...
