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Primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion: a literature review
PurposeThis review primarily aims to review the epidemiology, clinical characteristics, imaging, pathology, immunohistochemistry, diagnosis,...
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CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma
Multiple myeloma (MM) cells effectively escape anti-tumoral immunity to survive in the tumor microenvironment (TME). Herein, we identify...
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Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer
Ferroptosis is a type of regulated cell death characterized by iron accumulation and lipid peroxidation. The molecular mechanisms underlying...
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CREB1 Silencing Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking NF-κB Signaling
Apoptosis and inflammation of vascular endothelial cells (VECs) are the most important causes of deep vein thrombosis (DVT). cAMP response element...
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AKAP13 Enhances CREB1 Activation by FSH in Granulosa Cells
Granulosa cells (GCs) must respond appropriately to follicle-stimulating hormone (FSH) for proper follicle maturation. FSH activates protein kinase A...
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miR-125b-5p upregulation by TRIM28 induces cisplatin resistance in non-small cell lung cancer through CREB1 inhibition
ObjectivemiR-125b-5p plays an important role in the development of cancer and drug resistance. However, in cisplatin resistance of non-small cell...
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STAT3 regulates SRGN and promotes metastasis of nasopharyngeal carcinoma through the FoxO1-miR-148a-5p-CREB1 axis
Nasopharyngeal carcinoma (NPC), which is marked by a distinct distribution, is a common subtype of epithelial carcinoma arising from the...
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Correlation between variants of the CREB1 and GRM7 genes and risk of depression
The pathogenesis of depression involves cAMP -response element binding protein1 ( CREB1 ) and metabotropic glutamate receptor 7 ( GRM7 ), and their...
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Silencing of circ_0007299 suppresses proliferation, migration, and invasiveness and promotes apoptosis of ectopic endometrial stromal cells in endometriosis via miR-424-5p-dependent modulation of CREB1
BackgroundThe abnormality of endometrial stromal cells (ESCs) can contribute to endometriosis pathogenesis. Circular RNAs (circRNAs) possess critical...
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Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation
The molecular mechanisms of luminal cell differentiation are not understood well enough to determine how differentiation goes awry during...
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Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population
Genetic factors play a crucial role for the pathophysiology of treatment-resistant depression (TRD). It has been established that Catechol- O -methyltra...
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GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies
Cancer cells are usually characterized by hyperactive glucose metabolism, which can often lead to glucose scarcity; thus, alternative pathways to...
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Myxoid mesenchymal intraventricular brain tumour with EWSR1–CREB1 gene fusion in an adult woman
Myxoid mesenchymal tumours harbouring fusions between EWSR1 and the CREB family transcription factors have recently been described. Whether they...
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Primary pulmonary myxoid sarcoma in the interlobar fissure of the left lung lobe: a case report
BackgroundPrimary pulmonary myxoid sarcoma (PPMS) is a rare, low-grade malignant tumor, constituting approximately 0.2% of all lung tumors. Despite...
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Genetic association study for three single nucleotide polymorphisms related to type 2 diabetes in Egyptian population
BackgroundDiabetes mellitus is a disease that may result from interaction between environmental factors and a strong genetic component. The current...
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Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature
BackgroundPrimary pulmonary myxoid sarcoma (PPMS) is an extremely rare lung sarcoma that is characterized in most cases by recurrent balanced...
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Intracranial myxoid mesenchymal tumor with EWSR1–CREB1 gene fusion: a case report and literature review
Intracranial myxoid mesenchymal tumors harboring EWSR1 fusions with CREB transcriptional factor gene families were recently described in several case...
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Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling
Frequent relapse and chemoresistance cause poor outcome in ovarian cancer (OC) and cancer stem cells (CSCs) are important contributors. While most...
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Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium
The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation causes a syndromic form of autism spectrum disorder (ASD):...
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Primary pulmonary myxoid sarcoma with an unusual gene fusion between exon 7 of EWSR1 and exon 5 of CREB1
Primary pulmonary mesenchymal tumors are rare, yet they compromise a variety of entities. A novel low-grade malignant neoplasm coined primary...
