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COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma
BackgroundPancreatic adenocarcinoma (PAAD) is a lethal malignant tumour. Further study is needed to determine the molecular mechanism and identify...
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Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
ObjectiveTo investigate the effect of COVID-19 infection on pancreatic cancer.
MethodsBased on the mRNA-Seq data of COVID-19 patients and pancreatic...
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Screening and Analysis of Core Genes for Osteoporosis Based on Bioinformatics Analysis and Machine Learning Algorithms
ObjectiveThis study aimed to identify osteoporosis-related core genes using bioinformatics analysis and machine learning algorithms.
Methods ...
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Biallelic variants in SLC26A2 cause multiple epiphyseal dysplasia-4 by disturbing chondrocyte homeostasis
BackgroundMultiple epiphyseal dysplasia-4 (MED-4, MIM 226900) is a rare autosomal recessive disease characterized by disproportionate height and...
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Temporomandibular Joint Fibrocartilage Contains CD105 Positive Mouse Mesenchymal Stem/Progenitor Cells with Increased Chondrogenic Potential
ObjectiveA specific type of mesenchymal stem/progenitor cells (MSPCs), CD105 + is reported to aid in cartilage regeneration through...
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Schmid Type Metaphyseal Chondrodysplasia with a Novel COL10A1 Mutation
Schmid type metaphyseal chondrodysplasia (SMCD) is a rare skeletal dysplasia, characterized by short stature, short limbs, bowing of the legs, and...
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Identifying the key genes regulating mesenchymal stem cells chondrogenic differentiation: an in vitro study
BackgroundMesenchymal stem cells (MSCs) possess the potential to differentiate into chondrocytes, which makes them an ideal source for healing...
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Impaired function of skeletal stem cells derived from growth plates in ovariectomized mice
IntroductionMouse skeletal stem cells (mSSCs, CD45 − Ter119 − Tie2 − CD51 + Thy − 6C3 − CD105 − CD200 + population) are identified in growth plates (GP) and play...
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Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
ObjectiveTo characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology...
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Comparative in vitro treatment of mesenchymal stromal cells with GDF-5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy
PurposeHypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis....
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Keloids are transcriptionally distinct from normal and hypertrophic scars
BackgroundWound healing and skin regeneration after injury are complex biological processes, and deep injuries with a high degree of tissue...
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LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice
The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion. Here, we report that...
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Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis
IntroductionLikely due to ignored heterogeneity in disease pathophysiology, osteoarthritis (OA) has become the most common disabling joint disease,...
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Bevacizumab suppressed degenerative changes in articular cartilage explants from patients with osteoarthritis of the knee
BackgroundThis study was designed to test the hypothesis that blockade of vascular endothelial growth factor (VEGF) suppresses degenerative changes...
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Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models
Purpose of ReviewTo illustrate the value of using zebrafish to understand the role of the Fgf signaling pathway during craniofacial skeletal...
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Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
IntroductionSelenium (Se) as well as selenoproteins are vital for osteochondral system development. Se deficiency (SeD) has a definite impact on the...
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Deer antler extract promotes tibia fracture healing in mice by activating BMP-2/SMAD4 signaling pathway
BackgroundDeer antler is a traditional Chinese medicine with the function of tonifying kidney and strengthening bone, which is often used to treat...
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Insights into skeletal stem cells
The tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent, continuously provide cells (including chondrocytes, bone...
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Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways
Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are...
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