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Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
BackgroundAdipokines, including adiponectin, are implicated in nociceptive pain; however, the underlying cellular and molecular mechanisms remain...
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Titin and CK2α are New Intracellular Targets in Acute Insulin Application-Associated Benefits on Electrophysiological Parameters of Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic Syndrome Rats
BackgroundPrevious studies have demonstrated that a high-carbohydrate intake could induce metabolic syndrome (MetS) in male rats with marked cardiac...
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Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity
Mitochondrial fusion/fission dynamics plays a fundamental role in neuroprotection; however, there is still a severe lack of therapeutic targets for...
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Regulation of cancer progression by CK2: an emerging therapeutic target
Casein kinase II (CK2) is an enzyme with pleiotropic kinase activity that catalyzes the phosphorylation of lots of substrates, including STAT3, p53,...
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CK2 activity is crucial for proper glucagon expression
Aims/hypothesisProtein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly mediated by...
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Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors
Poly[ADP-ribose] polymerase (PARP) inhibitors, which selectively kills homologous recombination (HR) repair-deficient cancer cells, are widely...
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Roles of NOLC1 in cancers and viral infection
BackgroundThe nucleolus is considered the center of metabolic control and an important organelle for the biogenesis of ribosomal RNA (rRNA)....
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Hypoxia switches TET1 from being tumor-suppressive to oncogenic
The classical oxidizing enzymatic activity of Ten Eleven Translocation 1 (TET1) and its tumor suppressor role are well known. Here, we find that high...
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P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant...
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Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma
PurposeAlthough gemcitabine-based chemotherapy is most recommended for pancreatic ductal adenocarcinoma (PDAC), its effectiveness is limited because...
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Mitophagy for cardioprotection
Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively termed mitochondrial quality control mechanisms,...
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RETRACTED ARTICLE: NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α
Mitochondrial fission and mitophagy are considered key processes involved in the pathogenesis of cardiac microvascular ischemia reperfusion (IR)...
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The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells
Cholangiocarcinoma (CCA) is a particularly aggressive hepatobiliary malignancy, for which the molecular mechanisms underlying the malignant phenotype...
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Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is...
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Two different presentations of de novo variants of CSNK2B: two case reports
BackgroundPoirier–Bienvenu neurodevelopmental syndrome is a neurologic disorder caused by mutations in the CSNK2B gene. It is mostly characterized...
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CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K–Akt pathway and epithelial–mesenchymal transition
BackgroundMultiple studies have established a strong relationship between circRNA and cancer progression. Cervical lymph node metastasis is a key...
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Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia
Children of Hispanic/Latino ancestry have increased incidence of high-risk B-cell acute lymphoblastic leukemia (HR B-ALL) with poor prognosis. This...
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Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4
Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic...
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Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance
Aberrant function of epigenetic modifiers plays an important role not only in the progression of cancer but also the development of drug resistance....
