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Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy
CD27 is a costimulatory molecule that provides a complementary target to the PD-1/PD-L1 checkpoint axis on T cells. Combining a CD27 agonist antibody...
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Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice
Cyclophosphamide plus fludarabine (C/F) are currently used to improve the expansion and effectiveness of adoptive cell therapy (ACT). However, these...
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T cells in health and disease
T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and...
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A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains
Chimeric antigen receptors (CARs) are engineered proteins designed to target T cells to cancer cells. To effectively activate the T cells in which...
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Counteracting CAR T cell dysfunction
In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by...
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Immune checkpoint targeting antibodies hold promise for combinatorial cancer therapeutics
Through improving the immune system's ability to recognize and combat tumor cells as well as its receptivity to changes in the tumor...
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Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes
BackgroundAnkylosing spondylitis (AS) is a rare inflammatory disorder affecting the spinal joints. Although we know some of the genetic factors that...
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Characteristics of premanufacture CD8+ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma
Although chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies,...
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Current Clinical Trial Landscape of OX40 Agonists
Purpose of ReviewDespite the efficacy of immune checkpoint blockade (ICB) immunotherapy, most cancer patients still develop progressive disease...
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5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma
Background5-Methylcytosine (m 5 C) methylation is recognized as an mRNA modification that participates in biological progression by regulating related...
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T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review
X-linked agammaglobulinaemia (XLA) is a primary immunodeficiency (PID) resulting from a defect in the B cell development. It has conventionally been...
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Mitigated suppressive function of regulatory T cells (Treg) upon Th17-inducing cytokines in oligo- and polyarticular Juvenile Idiopathic Arthritis (JIA) patients
BackgroundThe plasticity of T helper-17 (Th17) and regulatory T (Treg) cells may be a clue to pathogenesis of Juvenile Idiopathic Arthritis (JIA). It...
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Atypical Memory and Regulatory B Cell Subsets in Tumor Draining Lymph Nodes of Head and Neck Squamous Cell Carcinoma Correlate with Good Prognostic Factors
Research on the role of B cells in the development and modulation of antitumor immunity has increased in recent years; however, knowledge about B...
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Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes
ObjectivePseudogenes are initially regarded as nonfunctional genomic sequences, but some pseudogenes regulate tumor initiation and progression by...
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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis
The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported...
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A Head Start: CAR-T Cell Therapy for Primary Malignant Brain Tumors
Oncology is in the midst of a therapeutic renaissance. The realization of immunotherapy as an efficacious and expanding treatment option has...
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Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates
Merkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine differentiation. Its carcinogenesis is based either on the...
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Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells
BackgroundStandard treatment of oropharyngeal squamous cell carcinoma (OPSCC) is associated with high morbidity, whereas immunotherapeutic approaches...
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TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond
The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2, and is a central mediator of various immune-mediated diseases....
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Recent advances in CAR-T cell engineering
Chimeric antigen receptor T (CAR-T) cell therapy is regarded as an effective solution for relapsed or refractory tumors, particularly for...
