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Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
BackgroundChromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene silencer. Our...
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Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes
Chromobox (CBX)2 and CBX7, members of CBX family protein, show diverse expression patterns and contrasting roles in certain cancers. We aimed to...
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Decoding the interaction between miR-19a and CBX7 focusing on the implications for tumor suppression in cancer therapy
Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth, genetic alterations, and disruption of normal cellular...
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CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic potential
Deaths from ovarian cancer usually occur when patients succumb to overwhelmingly numerous and widespread micrometastasis. Whereas...
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In Vivo Genome-Wide PGR Binding in Pregnant Human Myometrium Identifies Potential Regulators of Labor
The alterations in myometrial biology during labor are not well understood. The myometrium is the contractile portion of the uterus and contributes...
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Effect of CBX7 deficiency on the socket healing after tooth extractions
CBX7 is shown to down-regulate the expression of osteopontin (OPN) that is associated with osteoblast function. Here, we studied the role of CBX7 in...
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Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis
BackgroundAdult hippocampal neurogenesis (AHN) is a clinically significant neural phenomenon. Understanding its molecular regulation would be...
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CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-ÎşB-miR-21 pathways
BackgroundChromobox protein homolog 7 (CBX7), a member of the polycomb group (PcG) family of proteins, is involved in the regulation of cell...
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RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences
The chronic lymphocytic leukemia (CLL) armamentarium has evolved significantly, with novel therapies that inhibit Bruton Tyrosine Kinase, PI3K delta...
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Resveratrol effects in oral cancer cells: a comprehensive review
Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and...
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MiR-18a affects hypoxia induced glucose metabolism transition in HT22 hippocampal neuronal cell line through the Hif1a gene
Hypoxia can cause a variety of diseases, including ischemic stroke and neurodegenerative diseases. Within a certain range of partial pressure of...
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Exosomal circRNA: emerging insights into cancer progression and clinical application potential
Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as...
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Shared genetic loci and causal relations between schizophrenia and obsessive-compulsive disorder
Based on the clinical overlap between schizophrenia (SCZ) and obsessive-compulsive disorder (OCD), both disorders may share neurobiological...
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Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females
PurposeThe mechanisms contributing to recurrence of glioblastoma (GBM), an aggressive neuroepithelial brain tumor, remain unknown. We have recently...
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MicroRNA-128 acts as a suppressor in the progression of gastrointestinal stromal tumor by targeting B-lymphoma Mo-MLV insertion region 1
IntroductionThe critical role of microRNA-128 (miR-128) in gastrointestinal-related diseases has been documented. In the current study, we tried to...
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CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability
Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is...
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AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation
Polycomb repressor complex 1 (PRC1) is linked to the regulation of gene expression and histone ubiquitylation conformation, which contributes to...
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Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish
ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually...
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Ovarian clear cell carcinoma with or without endometriosis origin in a single institution cohort
BackgroundAs ovarian clear cell carcinoma (OCCC) has distinct clinical features, biology, genetic characteristics and mechanisms of pathogenesis, and...
