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Toll-like receptor 5-mediated signaling enhances liver regeneration in mice
BackgroundToll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective...
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Therapeutic applications of toll-like receptors (TLRs) agonists in AML
Acute myeloid leukemia (AML) is an aggressive type of blood cancer affecting bone marrow (BM). In AML, hematopoietic precursors are arrested in the...
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TLR5 agonist in combination with anti-PD-1 treatment enhances anti-tumor effect through M1/M2 macrophage polarization shift and CD8+ T cell priming
Immune checkpoint inhibitors have revolutionized anti-tumor therapy, notably improving treatment responses in various tumors. However, many patients...
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The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
Approximately 60–80% of cancer patients treated with abdominopelvic radiotherapy suffer post-radiotherapy toxicities including radiation enteropathy...
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Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments
Treatment for cancer has the potential to significantly diminish fertility and, further, to negatively impact the obstetrical outcomes of pregnancies...
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The pathogenesis of mucositis: updated perspectives and emerging targets
Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO...
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Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy
Toll-like receptor 5 (TLR5) is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered...
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Harnessing innate immune pathways for therapeutic advancement in cancer
The innate immune pathway is receiving increasing attention in cancer therapy. This pathway is ubiquitous across various cell types, not only in...
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Targeting Toll-Like Receptors for Cancer Therapy
The immune system encompasses a broad array of defense mechanisms against foreign threats, including invading pathogens and transformed neoplastic...
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Role of thrombocytopenia in radiation-induced mortality and review of therapeutic approaches targeting platelet regeneration after radiation exposure
BackgroundPreclinical studies on irradiated animals show that thrombocytopenia can play a role in radiation mortality, particularly in animals...
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Radioprotection of normal tissue cells
Improvements of radiotherapy in combination with surgery and systemic therapy have resulted in increased survival rates of tumor patients. However,...
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High expression of Toll-like receptor 5 correlates with better prognosis in non-small-cell lung cancer: an anti-tumor effect of TLR5 signaling in non-small cell lung cancer
PurposeToll-like receptor 5 (TLR5) is a pattern recognition receptor and plays key roles in inflammatory responses against pathogen infection....
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Toll-like receptors in urothelial cells—targets for cancer immunotherapy
Toll-like receptors (TLRs) have an important role in the activation of both innate and adaptive immunity in response to pathogens and danger signals....
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The Yin and Yang of Toll-like receptors in cancer
Recognition of non-self molecular patterns by pattern recognition receptors is a cornerstone of innate immunity. Toll-like receptors (TLRs) exert a...
