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Association of the serum levels of saturated fatty acids and mild cognitive impairment: a cross-sectional study
ObjectivesTo investigate the association of serum saturated fatty acids (SFAs) and prevalent mild cognitive impairment (MCI) among middle-aged and...
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Study of microencapsulated fatty acid antimicrobial activity in vitro and its prevention ability of Clostridium perfringens induced necrotic enteritis in broiler chicken
BackgroundNecrotic enteritis (NE) is an infectious intestinal disease caused by Clostridium perfringens ( C. perfringens ) that is now re-emerging and...
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Efficacy, safety, and pharmacokinetics of teduglutide in adult Japanese patients with short bowel syndrome and intestinal failure: two phase III studies with an extension
PurposeThe short- and long-term efficacy, safety, and pharmacokinetics of teduglutide were analyzed in adult Japanese patients with short bowel...
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Circulating amino acids and acylcarnitines correlated with different CAC score ranges in diabetic postmenopausal women using LC–MS/MS based metabolomics approach
BackgroundDiabetes mellitus (DM) and its cardiovascular disease (CVD) complication are among the most frequent causes of death worldwide. However,...
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Plasma acylcarnitines and amino acids in dyslipidemia: An integrated metabolomics and machine learning approach
PurposeThe Discovery of underlying intermediates associated with the development of dyslipidemia results in a better understanding of pathophysiology...
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Severity estimation of very-long-chain acyl-CoA dehydrogenase deficiency via 13C-fatty acid loading test
BackgroundThe clinical severity of very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is difficult to predict using conventional diagnostic...
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Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men
BackgroundMetabolic profiling may provide insights into the pathogenesis and identification of sarcopenia; however, data on the metabolic basis of...
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Establishment of a real-time fluorescent quantitative PCR detection method and phylogenetic analysis of BoAHV-1
BackgroundInfectious bovine rhinotracheitis (IBR), caused by Bovine alphaherpesvirus-1 (BoAHV-1), is an acute, highly contagious disease primarily...
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A novel mutation in ACADVL causing very long-chain acyl-coenzyme-A dehydrogenase deficiency in a South Asian pediatric patient: a case report and review of the literature
BackgroundVery long-chain acyl-coenzyme-A dehydrogenase deficiency is a rare, severe life-threatening metabolic disorder of mitochondrial fatty acid...
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Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry
BackgroundThe circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with...
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The first detection of quaternary ammonium compounds in breast milk: Implications for early-life exposure
BackgroundQuaternary ammonium compounds (QACs), commonly used in cleaning, disinfecting, and personal care products, have recently gained worldwide...
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Plasma metabolomic profiles associated with hypertension and blood pressure in response to thiazide diuretics
This study aimed to identify the metabolomic alterations associated with hypertension (HTN) and the response of blood pressure (BP) to thiazide...
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The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes
Aims/hypothesisOur aim was to characterise the in-depth metabolic response to aerobic exercise and the impact of residual pancreatic beta cell...
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Mundhöhlen- und Pharynxkarzinome: Inzidenz, Mortalität und Überleben in Deutschland
BackgroundLip, oral cavity, and pharynx cancers (ICD-10: C00–C14) describe a heterogeneous group of tumors with strong variations in incidence,...
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Oral cancer awareness campaign in Northern Germany: first positive trends in incidence and tumour stages
PurposeOral cancer is a still underestimated public health problem. In Germany, until 2007, there was no systematic approach available for the...
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Kerosene condenses in the trachea following inhalation
PurposeWe have investigated the absorption dynamics of petroleum fuel components from the analytical results of autopsy samples.
Methods ...
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The association and prediction value of acylcarnitine on diabetic nephropathy in Chinese patients with type 2 diabetes mellitus
BackgroundAcylcarnitines play a role in type 2 diabetes mellitus (T2DM), but the relationship between acylcarnitine and diabetic nephropathy was...
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Retrospective analysis of reference intervals for dried blood spot based ms/ms newborn screening programs in Chinese preterm neonates: a nationwide study
ObjectivesAlthough recent discoveries regarding the biomarkers of newborn screening (NBS) programs by tandem mass spectrometry (MS/MS) highlight the...
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Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia
Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP)....
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Mass spectrometry with derivatization method for concurrent measurement of amino acids and acylcarnitines in plasma of diabetic type 2 patients with diabetic nephropathy
BackgroundAmino acids (AAs) and acylcarnitines play a key role in metabolic disease and can be used as biomarkers of various diseases such as...