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Continuation Versus De-escalation of Broad-Spectrum Antibiotic Therapy in Critically Ill COVID-19 Patients
BackgroundAntibiotic de-escalation (ADE) is a stewardship initiative that aims to reduce exposure to antimicrobials, thus limiting their unwanted...
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Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation—is it really justified?
PurposeVery low birth weight (VLBW) infants are at a risk of spontaneous focal intestinal perforation (FIP). Treatment includes supportive care,...
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Early Empirical Use of Broad-Spectrum Antibiotics in Sepsis
Purpose of ReviewEarly antibiotic administration is the cornerstone of sepsis treatment guidelines and quality measures. We summarize recent key...
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Estimating the Treatment and Prophylactic Economic Value of New Antimicrobials in Managing Antibiotic Resistance and Serious Infections for Common Pathogens in the USA: A Population Modelling Study
BackgroundAntimicrobial resistance is a growing public health concern. There is a global need to estimate the population-level value of develo**...
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Assessment of home storage of antimicrobials and its predictors in Mecha demographic surveillance and field research center: a cross-sectional study
BackgroundHome storage of antimicrobials is a worldwide practice. Irrational storage and inappropriate use of antimicrobials should get special...
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Effects of the cefazolin shortage on the sales, cost, and appropriate use of other antimicrobials
BackgroundShortages of antimicrobials lead to treatment failures, increase medical costs, and accelerate the development of antimicrobial resistance....
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Use of antimicrobials in pediatric wards of five Brazilian hospitals
The use of antimicrobials (AMs) in pediatric infections is common practice and use may be inappropriate leading to antimicrobial resistance....
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Long Story Short: Establishing Breakpoints for Antimicrobials and 2023 Updates
Purpose of ReviewThis review outlines the process of setting and revising Clinical and Laboratory Standards Institute (CLSI) breakpoints and...
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Use of monitoring indicators in hospital management of antimicrobials
BackgroundAccording to the literature, 25% to 50% of antimicrobials prescribed in hospitals are unnecessary or inappropriate, directly impacting...
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Bacteriophage-derived endolysins as innovative antimicrobials against bovine mastitis-causing streptococci and staphylococci: a state-of-the-art review
Bacteriophage-encoded endolysins, peptidoglycan hydrolases breaking down the Gram-positive bacterial cell wall, represent a groundbreaking class of...
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Compliance with antibiotic therapy guidelines in french paediatric intensive care units: a multicentre observational study
BackgroundBacterial infections (BIs) are widespread in ICUs. The aims of this study were to assess compliance with antibiotic recommendations and...
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A Needs Assessment for Infectious Diseases Consultation in Community Hospitals
IntroductionInfectious diseases (ID) consultations have been demonstrated to improve patient outcomes in the treatment of severe infections. However,...
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Bacteraemia caused by Lactobacillus casei in a patient after cardiac surgery. A case report
BackgroundBacteria of the Lactobacillus family are a part of the physiological flora of the oral cavity, gastrointestinal tract, and urinary tract....
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Prescribing and sales of intramammary antimicrobials in Ireland in 2019 and 2020: the role of milk purchasers
BackgroundIn Ireland between 2008 and 2022, intramammary antimicrobial (AM) products could be prescribed by a veterinary practitioner under what was...
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The Role of Systemic Antimicrobials in the Treatment of Endophthalmitis: A Review and an International Perspective
BackgroundThe optimal management of patients with endophthalmitis is challenging and includes both intravitreal and, in some cases, systemic...
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The rapid detection of respiratory pathogens in critically ill children
PurposeRespiratory infections are the most common reason for admission to paediatric intensive care units (PICU). Most patients with lower...
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Capturing Value Attributes in the Economic Evaluation of Ceftazidime with Avibactam for Treating Severe Aerobic Gram-Negative Bacterial Infections in the United Kingdom
IntroductionAntimicrobial resistance remains a serious and growing threat to public health, both globally and in the UK, leading to diminishing...
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Point-of-care urine Gram stain led to narrower-spectrum antimicrobial selection for febrile urinary tract infection in adolescents and adults
BackgroundFebrile urinary tract infections (fUTIs), which include pyelonephritis, prostatitis, and urosepsis, are the most common cause of sepsis....
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Nationwide cross-sectional study of antimicrobial stewardship and antifungal stewardship programs in inpatient settings in Japan
BackgroundTo prevent antimicrobial resistance, both antimicrobial stewardship (AMS) and antifungal stewardship (AFS) in inpatient settings are needed...
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Efficacy and safety of quinolones vs. other antimicrobials for the treatment of uncomplicated urinary tract infections in adults: a systematic review and meta-analysis
Introduction and hypothesisIn the present study, we aimed to compare the efficacy and safety of quinolones with trimethoprim-sulfamethoxazole...
