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Impairment of the GABAergic system in the anterior insular cortex of heroin-addicted males
Opioid addiction is a global problem, causing the greatest health burden among drug use disorders, with opioid overdose deaths top** the statistics...
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Derivation of Coagulation Phenotypes and the Association with Prognosis in Traumatic Brain Injury: A Cluster Analysis of Nationwide Multicenter Study
BackgroundThe pathogenesis and pathophysiology of traumatic coagulopathy during traumatic brain injury is not well understood, and the appropriate...
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Inverse pattern of GABAergic system impairment in the external versus internal globus pallidus in male heroin addicts
Opioid addiction is a global problem that has been exacerbated in the USA and Europe by the COVID-19 pandemic. The globus pallidus (GP) plays a...
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Ribosomal DNA transcription is increased in the left nucleus accumbens of heroin-dependent males
Opioid addiction is a worldwide problem accentuated in the USA and European countries by the COVID-19 pandemic. The nucleus accumbens (NAc) plays an...
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Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson’s disease in the Chinese population
BackgroundSeveral studies have indicated that skin holds promise as a potential sample for detecting pathological α-Syn and serving as a diagnostic...
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The Association Between D-dimer Levels and Long-Term Neurological Outcomes of Patients with Traumatic Brain Injury: An Analysis of a Nationwide Observational Neurotrauma Database in Japan
BackgroundWe evaluated the association between D-dimer (DD) levels and long-term neurological prognoses among patients with isolated traumatic brain...
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Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies
The retina is a potential source of biomarkers for the detection of neurodegenerative diseases. Accumulation of phosphorylated tau (p-tau) in the...
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Establishing severity levels for patient-reported measures of functional communication, participation, and perceived cognitive function for adults with acquired cognitive and language disorders
PurposeTo empirically assign severity levels (e.g., mild , moderate ) to four relatively new patient-reported outcome measures (PROMs) for adults with...
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Characteristics of ocular injuries associated with mortality in patients admitted with major trauma
BackgroundFew ocular trauma studies have addressed mortality outcomes. We sought to determine characteristics of mortality-related ocular trauma...
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Clinical and pathological characteristics of later onset multiple system atrophy
BackgroundIn the current consensus criteria, onset after age 75 is considered as non-supporting for diagnosis of multiples system atrophy (MSA);...
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Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions
Multiple sclerosis (MS) is a heterogeneous neurological disorder with regards to clinical presentation and pathophysiology. Here, we investigated the...
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Injury patterns and outcomes in motorcycle passengers
IntroductionContemporary trauma literature on injuries to motorcycle passengers is scarce. The aim of this study was to examine the injury patterns...
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Retinal functional and structural changes in patients with Parkinson’s disease
BackgroundVisual dysfunction have been well reported as one of the non-motor symptoms in Parkinson’s disease (PD). The aim of this study was to...
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Association between major dietary patterns and Parkinson’s disease risk: a case–control study
BackgroundThere has been emerging attention to investigate the possible role of some dietary factors in the pathogenesis of Parkinson’s disease (PD);...
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Promise and challenges of dystonia brain banking: establishing a human tissue repository for studies of X-Linked Dystonia-Parkinsonism
X-Linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease affecting individuals with ancestry to the island of Panay in the Philippines. In...
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Sporadic adult-onset neuronal intranuclear inclusion disease without high-intensity signal on DWI and T2WI: a case report
BackgroundNeuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease characterized by eosinophilic hyaline intranuclear...
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Mild traumatic brain injury: not always a mild injury
PurposeIn general, risk of mortality after trauma correlates with injury severity. Despite arriving in relatively stable clinical condition, however,...
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Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein
The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrP Sc ,...
