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Pathological Complete Response as Outcome Modifier in Breast Cancer Patients and Brain Metastasis
Breast cancer with brain metastases (BCBM) has dreadful outcomes. Various factors influencing outcomes are age, receptors status, number of distant...
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The role of microRNAs in brain metastasis
Brain metastasis (BM) is the most common type of brain tumor and frequently foreshadows disease progression and poor overall survival with patients...
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ITGB4 is a prognostic biomarker and correlated with lung adenocarcinoma brain metastasis
BackgroundThe aim of this study is to explore the prognostic value and immune signature of ITGB4 expression in lung adenocarcinoma (LUAD) brain...
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Natural history of spinal cord metastasis from brain glioblastomas
Background and ObjectivesSpinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the...
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ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells
BackgroundTriple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on...
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Identification of a gene expression signature associated with brain metastasis in colorectal cancer
PurposeBrain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung and bone metastasis no...
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Coordination of anti-CTLA-4 with whole-brain radiation therapy decreases tumor burden during treatment in a novel syngeneic model of lung cancer brain metastasis
Lung cancer is the most common primary tumor to metastasize to the brain. Although advances in lung cancer therapy have increased rates of survival...
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Immune related biomarkers for cancer metastasis to the brain
Brain metastasis accounts for a large number of cancer-related deaths. The host immune system, involved at each step of the metastatic cascade, plays...
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Breast-to-Brain Metastasis: from Microenvironment to Plasticity
Abstract Purpose of ReviewBrain metastasis is a significant cause of mortality in breast cancer patients and treatment options are limited. This...
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The relationship between brain metastasis and HER2 expression status in gastric cancer
BackgroundBrain metastasis (BM) in gastric cancer (GC) is underestimated, and human epidermal growth factor receptor 2 (HER2) overexpression is a...
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Extracranial metastasis sites correlate to the incidence risk of brain metastasis in stage IV non-small cell lung cancer: a population-based study
PurposeThe aim of this study was to analyse the correlation of extracranial metastasis sites (ECMs) to the incidence risk of brain metastasis (BMs)...
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Systemic Treatment for Brain Metastasis and Leptomeningeal Disease in Breast Cancer Patients
Purpose of ReviewBreast cancer with brain metastasis (BCBM) and leptomeningeal disease (LMD) are important clinical problems. Traditionally, patients...
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Brain metastasis in breast cancer: focus on genes and signaling pathways involved, blood–brain barrier and treatment strategies
Breast cancer (BC) is one of the most prevalent types of cancer in women. Despite advancement in early detection and efficient treatment, recurrence...
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Using machine learning-based radiomics to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes
ObjectiveTo establish a machine learning-based radiomics model to differentiate between glioma and solitary brain metastasis from lung cancer and its...
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Long term survivors of stereotactic radiosurgery for brain metastases: do distant brain failures reach a plateau and what factors are associated with a brain metastasis velocity of zero?
PurposeLife expectancy continues to increase for patients with brain metastases treated with stereotactic radiosurgery (SRS). The present study...
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68Ga-DOATATOC Brain PET/CT Imaging in a case of Dural Metastasis from Synovial Sarcoma
We present the case of a 70-year-old male patient who underwent a gallium-68 ( 68 Ga)-DOTATOC brain positron emission tomography (PET)/computed...
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CHD5 gene variant predicts leptomeningeal metastasis after surgical resection of brain metastases of breast cancer
PurposeLeptomeningeal metastasis (LM) is a complication of surgery for brain metastasis and is a risk factor of poor prognosis. The risk of LM is...
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Treatment and survival of patients with small cell lung cancer and brain metastasis
PurposeTo elucidate treatment patterns and their outcomes in patients with small cell lung cancer (SCLC) and brain metastasis (BM).
Methods ...
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Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review
PurposeA systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying...
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Laser interstitial thermal therapy followed by consolidation stereotactic radiosurgery (LITT-cSRS) in patients with newly diagnosed brain metastasis
IntroductionThe efficacy and safety of laser interstitial thermal therapy followed by consolidation radiosurgery (LITT-cSRS) was previously studied...
