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Longitudinal changes in brain metabolites in healthy controls and patients with first episode psychosis: a 7-Tesla MRS study
Seven Tesla magnetic resonance spectroscopy (7T MRS) offers a precise measurement of metabolic levels in the human brain via a non-invasive approach....
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Measurement of Δ9THC and metabolites in the brain and peripheral tissues after intranasal instillation of a nanoformulation
BackgroundComparative bioavailability of cannabinoids following their administration by dosing routes has been studied previously, but there are no...
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Impact of Bariatric Surgery on Circulating Metabolites and Cognitive Performance
IntroductionBariatric surgery is an effective intervention to reduce obesity and improve associated comorbidities. However, its effects on cognitive...
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Heroin and its metabolites: relevance to heroin use disorder
Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at the end of the nineteenth century, its popularity as a...
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Circulating metabolites modulated by diet are associated with depression
Metabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex...
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Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library
BackgroundNatural products play a key role as potential sources of biologically active substances for the discovery of new drugs. This study aimed to...
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Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
Background:Cavernous angiomas (CAs) affect 0.5% of the population, predisposing to serious neurologic sequelae from brain bleeding. A leaky gut...
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Alterations in metabolites in the anterior cingulate cortex and thalamus and their associations with pain and empathy in patients with chronic mild pain: a preliminary study
Proton magnetic resonance spectroscopy ( 1 H-MRS) has shown inconsistent alterations in the brain metabolites of individuals with chronic pain. We used...
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Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In the...
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Tryptophan metabolites and gut microbiota play an important role in pediatric migraine diagnosis
BackgroundThe pathogenesis of pediatric migraine remains unclear and presents challenges in diagnosis. Recently, growing evidence has indicated that...
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Identification of blood metabolites associated with risk of Alzheimer’s disease by integrating genomics and metabolomics data
Specific metabolites have been reported to be potentially associated with Alzheimer’s disease (AD) risk. However, the comprehensive understanding of...
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Intestinal metabolites predict treatment resistance of patients with depression and anxiety
BackgroundThe impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on...
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Exploring the causal association between serum metabolites and erectile dysfunction: a bidirectional Mendelian randomisation study
Erectile dysfunction is a common sexual disorder in men. Some studies have found a strong association between some serum metabolites and erectile...
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Evaluation of the causal effects of blood metabolites on irritable bowel syndrome: Mendelian randomization
BackgroundIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, discomfort, and changes in...
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Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the gut microbiota is a key player in communication between...
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Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging
PurposeThis study aimed to detect age-related brain metabolic and microstructural changes in healthy human brains by the use of whole-brain proton...
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Global Energy Metabolism Deficit in Alzheimer Disease Brain
BackgroundThe understanding of Alzheimer’s disease (AD) has been dominated by the amyloid hypothesis. However, therapies targeting beta-amyloid have...
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Effect of aerobic exercise on brain metabolite profiles in the mouse models of methamphetamine addiction: LC-MS-based metabolomics study
Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms...
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Small molecule metabolites: discovery of biomarkers and therapeutic targets
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of...
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Analysis of brain networks and fecal metabolites reveals brain–gut alterations in premenopausal females with irritable bowel syndrome
Alterations in brain–gut–microbiome (BGM) interactions have been implicated in the pathogenesis of irritable bowel syndrome (IBS). Here, we apply a...
