Search
Search Results
-
Qiang**g tablets repair of blood-testis barrier dysfunction in rats via regulating oxidative stress and p38 MAPK pathway
BackgroundThe blood-testis barrier (BTB) is a physical barrier of the testis to prevent various exogenous substrates from entering apical...
-
The Gut Microbiota Contributes to the Development of LPS-Induced Orchitis by Disrupting the Blood-Testosterone Barrier in Mice
Orchitis is a frequent inflammatory reproductive disease that causes male infertility and a decline in sperm quality. Gut microbiota can regulate...
-
The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However,...
-
Transporter modulation of molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-brain barrier in a rat
BackgroundThe antiviral drug molnupiravir is an orally bioavailable prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC), which is used to...
-
The effect of gonadotropin-inhibitory hormone on steroidogenesis and spermatogenesis by acting through the hypothalamic–pituitary–testis axis in mice
Gonadotropin inhibitory hormone (GnIH) is essential for regulating the reproduction of mammals and inhibiting testicular activities in mice. This...
-
Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis
BackgroundCannabis consumption by pregnant women continues to increase worldwide, raising concerns about adverse effects on fetal growth and...
-
miR-122-5p regulates the tight junction of the blood-testis barrier of mice via occludin
BackgroundOccludin protein is the primary assembling protein of TJs and the structural basis for tight junction formation between Sertoli cells in...
-
Determination of M1/M2 Macrophage Polarization in Ipsilateral and Contralateral Rat Testis Tissue Following Unilateral Torsion/Detorsion
The present study investigates the changes in M1/M2 macrophage polarization resulting from unilateral testicular torsion in the bilateral testis. The...
-
Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis
BackgroundSertoli cell-only syndrome (SCOS) is the most serious pathological type of non-obstructive azoospermia. Recently, several genes related to...
-
The Interplay between Androgen and Gut Microbiota: Is There a Microbiota-Gut-Testis Axis
The gut microbiota, a large ecosystem interacting with the host, has been shown to affect the health and fitness of the host-microbial superorganism....
-
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether and how...
-
Protective effects of GHRH antagonists against hydrogen peroxide-induced lung endothelial barrier disruption
PurposeGrowth hormone-releasing hormone (GHRH) is a hypothalamic hormone, which regulates growth hormone release from the anterior pituitary gland....
-
Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function
Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively little is known about the potential effects of the virus on...
-
Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
The "epithelial barrier hypothesis" proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial...
-
Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial...
-
TBC1D20 Is Essential for Mouse Blood–Testis Barrier Integrity Through Maintaining the Epithelial Phenotype and Modulating the Maturation of Sertoli Cells
Sertoli cells are important for spermatogenesis not only by directly interacting with germ line cells in the seminiferous epithelium but also by...
-
9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation
BackgroundTestis is an immune privileged organ, which prevents the immune response against sperm antigens and inflammation. Testicular cells...
-
First clinical assessment of [18F]MC225, a novel fluorine-18 labelled PET tracer for measuring functional P-glycoprotein at the blood–brain barrier
Objective5-(1-(2-[ 18 F]fluoroethoxy))-[3-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-propyl]-5,6,7,8-tetrahydronaphthalen ([ 18 F]MC225) is a...
-
Effect of androgens on Sertoli cell maturation in human testis from birth to puberty
BackgroundAndrogens are well known to be necessary for spermatogenesis. The purpose of this study was to determine Sertoli cell responsiveness to...
-
Blood extracellular vesicles carrying brain-specific mRNAs are potential biomarkers for detecting gene expression changes in the female brain
The absence of non-invasive tests that can monitor the status of the brain is a major obstacle for psychiatric care. In order to address this need,...
