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Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections
BackgroundSelf-sampling of dried blood spots (DBS) offers new routes to gather valuable health-related information from the general population. Yet,...
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Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer risk for SA remains...
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Development of a blood proteins-based model for bronchopulmonary dysplasia prediction in premature infants
BackgroundBronchopulmonary dysplasia (BPD) is the most common chronic pulmonary disease in premature infants. Blood proteins may be early predictors...
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A genetic correlation scan identifies blood proteins associated with bone mineral density
BackgroundOsteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore...
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Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses
The objective of this study was to evaluate the associations of 92 maternal blood-based proteins with increased infant birth size. The study was...
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Tau proteins in blood as biomarkers of Alzheimer’s disease and other proteinopathies
Alzheimer’s disease (AD), the most common age-dependent neurodegenerative disorder, is characterized neuropathologically by extracellular Aβ plaques...
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Metabolomics efficiently discriminates monozygotic twins in peripheral blood
Monozygotic (MZ) twins cannot be distinguished using conventional forensic STR ty** because they present identical STR genoty**s. However, MZ...
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Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse
BackgroundMitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix...
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Nuclear transport proteins: structure, function, and disease relevance
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental...
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Age-Markers on the Red Blood Cell Surface and Erythrocyte Microparticles may Constitute a Multi-parametric Strategy for Detection of Autologous Blood Transfusion
BackgroundAutologous blood transfusion is one of the illicit strategies, banned by the World Anti-Do** Agency, to increase the levels of...
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Differential expression of coagulation pathway-related proteins in diabetic urine exosomes
BackgroundCoagulation function monitoring is important for the occurrence and development of diabetes. A total of 16 related proteins are involved in...
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Procoagulant activity of red blood cell microparticles in stored packed red blood cell units and its relation to ABO blood grou**
BackgroundThroughout the storage of blood, the red cells undergo alterations known as “storage lesions,” which involve shape changes and the...
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FGF21 modulates hippocampal cold-shock proteins and CA2-subregion proteins in neonatal mice with hypoxia–ischemia
BackgroundFibroblast growth factor 21 (FGF21) is a neuroprotectant with cognitive enhancing effects but with poorly characterized mechanism(s) of...
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Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus
Background and ObjectiveTinnitus would benefit from an objective biomarker. The goal of this study is to identify plasma biomarkers of constant and...
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SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk
ObjectiveWe quantified neutralizing SARS-CoV-2 antibody against spike protein (nAb) levels after vaccination and SARS-CoV-2 infection in maternal...
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Systemic interrogation of immune-oncology-related proteins in patients with locally advanced prostate cancer undergoing androgen deprivation and intensity-modulated radiotherapy
PurposeThe primary objective was to establish whether blood-based leucine-rich alpha-2-glycoprotein (LRG1) can predict outcomes in patients with...
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Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease
BackgroundHuman prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection...
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Changes in inflammatory proteins following platelet transfusion in a neonatal population
BackgroundStudies have demonstrated increased morbidity and mortality with platelet transfusions in the neonatal period. Platelets are as important...
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The role of miRNA-29b1, MMP-2, MMP-9 mRNAs, and proteins in early diagnosis of HCC
BackgroundHepatocellular carcinoma (HCC) is a common, serious malignancy with a dismal prognosis. As HCC is frequently missed in its early stages,...
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Optimization of Formaldehyde Fixative Concentration for Individual Blood Cells to Develop a Stabilized Blood Control for Automated Hematology Analyzers
In a modern haematology laboratory, the complete and differential counts of blood are performed using complex haematology auto analyzers. In order to...