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Blood–Brain Barrier Disruption for the Treatment of Primary Brain Tumors: Advances in the Past Half-Decade
Purpose of ReviewTo review relevant advances in the past half-decade in the treatment of primary brain tumors via modification of blood–brain barrier...
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Post-endovascular treatment, blood-brain barrier disruption, predicts patient outcomes better than pre-treatment status
ObjectivesBlood-brain barrier (BBB) disruption is an important pathological change after cerebral infarction that exacerbates brain injury. We aimed...
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FUS-mediated blood–brain barrier disruption for delivering anti-Aβ antibodies in 5XFAD Alzheimer’s disease mice
PurposeAmyloid-β (Aβ) peptides, the main component of amyloid plaques found in the Alzheimer's disease (AD) brain, are implicated in its...
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Methodological and ethical challenges in the use of focused ultrasound for blood–brain barrier disruption in neuro-oncology
BackgroundFocused ultrasound (FUS) shows promise for enhancing drug delivery to the brain by temporarily opening the blood–brain barrier (BBB), and...
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Visualization of Blood–Brain Barrier Disruption in Septic Mice with the New Method Based on in Vivo Imaging Technology
BackgroundDynamic monitoring of the blood–brain barrier (BBB) functional status in septic mice can help to explore the pathological mechanisms....
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Strategies to Improve Drug Delivery Across the Blood–Brain Barrier for Glioblastoma
Purpose of ReviewGlioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has...
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The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However,...
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Brain microvascular endothelial cells and blood-brain barrier dysfunction in psychotic disorders
Although there is convergent evidence for blood-brain barrier (BBB) dysfunction and peripheral inflammation in schizophrenia (SZ) and bipolar...
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Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability
As the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor...
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From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy
Considerable strides in medical interventions during the acute phase of traumatic brain injury (TBI) have brought improved overall survival rates....
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The blood-brain barrier in aging and neurodegeneration
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood...
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Blood–Brain Barrier Dysfunction in Hypertensive Disorders of Pregnancy
Purpose of ReviewThe incidence of hypertensive disorders of pregnancy (HDP), especially preeclampsia has increased significantly over the last two...
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Alzheimer’s disease and drug delivery across the blood–brain barrier: approaches and challenges
Alzheimer's disease (AD) is a diverse disease with a complex pathophysiology. The presence of extracellular β-amyloid deposition as neuritic plaques...
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Does interventional MRI-guided brain cryotherapy cause a blood–brain barrier disruption? Radiological analysis and perspectives
Glioblastoma is the most common primary malignant brain tumor with an incidence of 5/100,000 inhabitants/year and a 5-year survival rate of 6.8%....
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Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood–brain barrier dysfunction
BackgroundHematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently, especially in warfarin-associated...
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Brain metastasis in breast cancer: focus on genes and signaling pathways involved, blood–brain barrier and treatment strategies
Breast cancer (BC) is one of the most prevalent types of cancer in women. Despite advancement in early detection and efficient treatment, recurrence...
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Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood–brain barrier damage in ducks during Riemerella anatipestifer infection
Riemerella anatipestifer infection is characterized by meningitis with neurological symptoms in ducklings and has adversely affected the poultry...
