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Bladder Stones in Pediatric Patients with Bladder Dysfunction: a Review of Pathophysiology and Management
Purpose of ReviewBladder stones are a prevalent problem in children with neurogenic bladder that impact quality of life and subject patients to...
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Mast cell distribution and prevalence in the murine urinary bladder
BackgroundMast cells have been implicated in the pathology of various urinary bladder disorders. However, the distribution of mast cells throughout...
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High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1
ObjectiveBladder outlet obstruction (BOO) results in significant fibrosis in the chronic stage and elevated bladder pressure. Piezo1 is a type of...
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Management of Vaginal Prolapse After Orthotopic Bladder
Purpose of reviewPelvic organ prolapse is a well-understood clinical condition in many women that can lead to pelvic discomfort, sexual dysfunction,...
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Deletion of Nrf2 induced severe oxidative stress and apoptosis in mice model of diabetic bladder dysfunction
The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway has been confirmed as a therapeutic target for type 2 diabetes mellitus (T2DM),...
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Neuromodulation Following Spinal Cord Injury for Restoration of Bladder and Erectile Function
Purpose of ReviewNeuromodulation for the treatment of idiopathic overactive bladder has been well recognized, but its expanded use in the neurogenic...
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Establishment of an overactive bladder model in mice
BackgroundOveractive bladder (OAB) is a syndrome characterized by symptoms of urinary urgency, often accompanied by frequent urination and nocturia...
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Pathophysiological Mechanisms Involved in Overactive Bladder/Detrusor Overactivity
Purpose of ReviewTo examine the latest published findings on the pathophysiological mechanisms involved in the development of overactive bladder...
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Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review
BackgroundPatients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder cancer in advanced...
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Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Sex and gender disparities in bladder cancer have long been a subject of interest to the cancer research community, wherein men have a 4 times higher...
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Pediatric Overactive Bladder and the Role of Sacral Neuromodulation
Purpose of ReviewOveractive bladder is the most common cause of voiding dysfunction in the pediatric population. Bladder overactivity can be...
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Pediatric Trauma—Not Just Little Adults—Part 1: Differences in Physiology and Injury Patterns
Purpose of ReviewPediatric trauma patients are often evaluated at non-pediatric trauma centers. In this manuscript, we highlight the nuances in...
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Therapeutic Effects of AF219 on Interstitial Cystitis/Bladder Pain Syndrome Induced by Cyclophosphamide or Water Avoidance Stress in Rats
Introduction and hypothesisTo evaluate the effect of AF219, a P2X3 receptor antagonist, in animal models of interstitial cystitis/bladder pain...
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The dynamic roles of the bladder tumour microenvironment
Bladder cancer is a prevalent but currently understudied cancer type and patient outcomes are poor when it progresses to the muscle-invasive stage....
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Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification
BackgroundSignificant long-term neurologic disability occurs in survivors of pediatric cardiac arrest, primarily due to hypoxic-ischemic brain...
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Prostate Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?
Purpose of ReviewIn this review, the current literature available to patients and providers on the diagnosis and management of prostate cancer in...
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Mechanisms of Action for Diabetic Bladder Dysfunction — State of the Art
Purpose of ReviewDiabetes (DM) is a common cause of lower urinary tract symptoms (LUTS), known as diabetic bladder dysfunction (DBD). The phenotype...
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Botox Use in the Older Woman: An Advanced Bladder Treatment Option
Purpose of ReviewThis article focuses on challenges of caring for older women with urgency urinary incontinence (UUI), and asks how treatment...
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Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction
Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global public health. Treating systemic comorbidities has been one...
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CircRNA/miRNA/mRNA axis participates in the progression of partial bladder outlet obstruction
BackgroundMore and more evidence showed that circRNA/miRNA/mRNA axis played a vital role in the pathogenesis of some diseases. However, the role of...
