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The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide development
BackgroundAn increased number of resources are allocated on cancer biomarker discovery, but very few of these biomarkers are clinically adopted. To...
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Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov...
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Knee acoustic emissions as a noninvasive biomarker of articular health in patients with juvenile idiopathic arthritis: a clinical validation in an extended study population
BackgroundJoint acoustic emissions from knees have been evaluated as a convenient, non-invasive digital biomarker of inflammatory knee involvement in...
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Derivation and validation of a blood biomarker score for 2-day mortality prediction from prehospital care: a multicenter, cohort, EMS-based study
Identifying potentially life-threatening diseases is a key challenge for emergency medical services. This study aims at examining the role of...
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Analysis of optical coherence tomography biomarker probability detection in central serous chorioretinopathy by using an artificial intelligence-based biomarker detector
AimTo adopt a novel artificial intelligence (AI) optical coherence tomography (OCT)-based program to identify the presence of biomarkers associated...
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Identification of glycogene-based prognostic signature and validation of B3GNT7 as a potential biomarker and therapeutic target in breast cancer
BackgroundBreast cancer is the most common cancer worldwide, with the fifth highest mortality rate among all cancers and high risk of metastasis....
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Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis
BackgroundMachine Learning (ML) plays a crucial role in biomedical research. Nevertheless, it still has limitations in data integration and...
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Development and validation of a computed tomography–based immune ecosystem diversity index as an imaging biomarker in non-small cell lung cancer
ObjectivesTo date, there are no data on the noninvasive surrogate of intratumoural immune status that could be prognostic of survival outcomes in...
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Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Myasthenia gravis is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Informative biomarkers remain an...
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Biomarker-based staging of Alzheimer disease: rationale and clinical applications
Disease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzheimer disease (AD), is pivotal to...
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Integrated bioinformatics and validation reveal SOX12 as potential biomarker in colon adenocarcinoma based on an immune infiltration-related ceRNA network
PurposeThe primary objective of this study was to construct competing endogenous RNA (ceRNA) networks and evaluate the prognostic significance of...
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Biomarker in Hepatocellular Carcinoma
Liver cancer is one of the most prevalent types of cancer and a major contributor to the socioeconomic burden worldwide. The pathogenesis of...
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Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases
Definitive diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) relies on the examination of brain tissues for the pathological prion protein (PrP Sc ...
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Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade
BackgroundMathematical models of complex diseases, such as Alzheimer’s disease, have the potential to play a significant role in personalized...
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Logistic regression and other statistical tools in diagnostic biomarker studies
A biomarker is a measured indicator of a variety of processes, and is often used as a clinical tool for the diagnosis of diseases. While the...
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Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) responds poorly to systemic treatment, including new immunotherapeutic approaches. Biomarkers are urgently...
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Prognostic utility of a multi-biomarker panel in patients with suspected myocardial infarction
BackgroundThe accurate identification of patients with high cardiovascular risk in suspected myocardial infarction (MI) is an unmet clinical need....
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Validation of a deep-learning-based retinal biomarker (Reti-CVD) in the prediction of cardiovascular disease: data from UK Biobank
BackgroundCurrently in the United Kingdom, cardiovascular disease (CVD) risk assessment is based on the QRISK3 score, in which 10% 10-year CVD risk...
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Machine learning based biomarker discovery for chronic kidney disease–mineral and bone disorder (CKD-MBD)
IntroductionChronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and some other...
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Decoding the glycoproteome: a new frontier for biomarker discovery in cancer
Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting...
