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CD10 and Das1: a biomarker study using immunohistochemistry to subtype gastric intestinal metaplasia
BackgroundIntestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into...
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Differences in Breast Cancer Costs by Cancer Stage and Biomarker Subtype in New Zealand
BackgroundBreast cancer requires the greatest expenditure among all cancer types, and the costs vary by cancer stage and biomarker status.
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T1 and ADC histogram parameters may be an in vivo biomarker for predicting the grade, subtype, and proliferative activity of meningioma
ObjectiveTo investigate the value of histogram analysis of T1 map** and diffusion-weighted imaging (DWI) in predicting the grade, subtype, and...
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A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype
BackgroundAsthma is a heterogeneous disease; therefore, biomarkers that can assist in the identification of subtypes and direct therapy are highly...
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Upregulation of the histone γ-H2AX correlates with worse patient survival and basal-like subtype in pancreatic ductal adenocarcinoma
PurposePatients with pancreatic ductal adenocarcinoma (PDAC) have yet to experience significant benefits from targeted therapy. Olaparib is currently...
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Identification of adenoid subtype characterized with immune-escaped phenotype in lung squamous carcinoma based on transcriptomics
Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and its demarcation contributes to various therapeutic outcomes. However, a small...
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A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy
Personalized treatment approaches for patients with limited liver metastases from colorectal cancer are critically needed. By leveraging three large,...
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Machine learning based biomarker discovery for chronic kidney disease–mineral and bone disorder (CKD-MBD)
IntroductionChronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and some other...
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Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction
BackgroundRecently, two molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) have been proposed: the “Classical” and “Basal-like” subtypes,...
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HER2-Low Breast Cancer: a New Subtype?
Breast cancer (BC) guidelines subdivide the disease into three main groups, namely hormone receptor (HR)–positive HER2-negative, HER2-positive, and...
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Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis
BackgroundPANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune diseases. Rheumatoid...
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Identification of glycogene-based prognostic signature and validation of B3GNT7 as a potential biomarker and therapeutic target in breast cancer
BackgroundBreast cancer is the most common cancer worldwide, with the fifth highest mortality rate among all cancers and high risk of metastasis....
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Thyroid transcription factor‐1 expression in lung neuroendocrine tumours: a gender-related biomarker?
PurposeThyroid transcription factor‐1 (TTF‐1) assessed by immunohistochemistry (IHC) is a specific biomarker for lung adenocarcinoma, and is commonly...
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Mesenchymal-like immune-altered is the fourth robust triple-negative breast cancer molecular subtype
BackgroundRobust molecular subty** of triple-negative breast cancer (TNBC) is a prerequisite for the success of precision medicine. Today, there is...
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The proneural subtype is not associated with survival benefit from bevacizumab in newly diagnosed glioblastoma: a secondary analysis of the GLARIUS trial
PurposeThe AVAglio trial reported a significant survival benefit for first line bevacizumab treatment in patients with IDH wildtype glioblastoma of...
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Biomarker profile of invasive lobular carcinoma: pleomorphic versus classic subtypes, clinicopathological characteristics and prognosis analyses
PurposeTo compare the clinicopathologic features and prognosis of pleomorphic invasive lobular carcinoma (P-ILC) and classic ILC (C-ILC) according to...
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Epigenetically dysregulated NOTCH-Delta-HES signaling cascade can serve as a subtype classifier for acute lymphoblastic leukemia
The NOTCH-Delta-HES signaling cascade is regarded as a double-edged sword owing to its dual tumor-suppressor and oncogenic roles, in different...
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Radiomics and machine learning for renal tumor subtype assessment using multiphase computed tomography in a multicenter setting
ObjectivesTo distinguish histological subtypes of renal tumors using radiomic features and machine learning (ML) based on multiphase computed...
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Identification of biomarker candidates for exfoliative glaucoma from autoimmunity profiling
BackgroundExfoliative glaucoma (XFG) is a subtype of open-angle glaucoma characterized by distinctive extracellular fibrils and a yet unknown...
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FBP1 is a potential prognostic biomarker and correlated with tumor immunosuppressive microenvironment in glioblastoma
Hypoxia has been shown to contribute to tumor immunosuppressive microenvironment and is an effective prognostic indicator. This study aimed to screen...
