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Bioluminescence Imaging In Vivo Confirms the Viability of Pancreatic Islets Transplanted into the Greater Omentum
PurposeThe liver is the most widely used site for pancreatic islet transplantation. However, several site-specific limitations impair functional...
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The ATP bioluminescence assay: a new application and optimization for viability testing in the parasitic nematode Haemonchus contortus
The parasitic gastrointestinal nematode Haemonchus contortus causes serious economic losses to agriculture due to infection and disease in small...
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Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging
PurposeCurrently, a variety of red and green beetle luciferase variants are available for bioluminescence imaging (BLI). In addition, new luciferin...
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Outbreak investigation of Serratia marcescens bloodstream infection in an obstetric ward for high-risk pregnant women
BackgroundSerratia marcescens is a gram-negative bacterium that is widespread in the environment. S. marcescens bacteremia can be fatal during...
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Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography
Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer cells expressing specific antigens like human...
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Molecular fluorophores for in vivo bioimaging in the second near-infrared window
PurposeThis systematic review aims to summarize the current developments of fluorescence and chemi/bioluminescence imaging based on the molecular...
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Practical Guidance for Develo** Small-Molecule Optical Probes for In Vivo Imaging
The WMIS Education Committee (2019–2022) reached a consensus that white papers on molecular imaging could be beneficial for practitioners of...
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Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating therapeutic interventions....
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Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma
BackgroundGlioblastoma (GBM) is the most common primary brain tumor in adults. Despite extensive research and clinical trials, median survival...
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Reprogramming a Doxycycline-Inducible Gene Switch System for Bacteria-Mediated Cancer Therapy
PurposeAttenuated Salmonella typhimurium is a potential biotherapeutic antitumor agent because it can colonize tumors and inhibit their growth. The...
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Therapeutic efficacy of an alpha-particle emitter labeled anti-GD2 humanized antibody against osteosarcoma—a proof of concept study
PurposeCurrent treatments for osteosarcoma (OS) have a poor prognosis, particularly for patients with metastasis and recurrence, underscoring an...
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Bioluminescence and near-infrared fluorescence imaging for detection of metastatic bone tumors
Bioluminescence imaging is being increasingly utilized in biological research. However, since the most commonly used firefly luciferase generates...
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A mouse model of neoadjuvant chemotherapy followed by interval cytoreductive surgery indicates impaired efficacy of perioperative cisplatin
BackgroundInvestigate the impact of interval cytoreductive surgery (ICS) on progression in an orthotopic mouse model of ovarian cancer and the impact...
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Repurposing mebendazole against triple-negative breast cancer CNS metastasis
PurposeTriple-negative breast cancer (TNBC) often metastasizes to the central nervous system (CNS) and has the highest propensity among breast cancer...
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The collagenase of the bacterium Clostridium histolyticum does not favor metastasis of breast cancer
BackgroundBreast cancer is the most common malignancy among women worldwide. As survival rates increase, breast reconstruction and quality of life...
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Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents
BackgroundCurrent therapeutic agents, including nifurtimox and benznidazole, are not sufficiently effective in the chronic phase of Trypanosoma cruzi ...
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Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
BackgroundEGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR or HER2xHER2) and...
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Early-Phase Luciferase Signals of Islet Grafts Predicts Successful Subcutaneous Site Transplantation in Rats
PurposeThe transplantation of pancreatic islets is a promising cell replacement therapy for type 1 diabetes. Subcutaneous islet transplantation is...
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Evaluation of the complexity of indoor air in hospital wards based on PM2.5, real-time PCR, adenosine triphosphate bioluminescence assay, microbial culture and mass spectrometry
BackgroundThe aim of this study was to establish a set of assessment methods suitable for evaluating the complex indoor environment of hospital wards...
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Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer
BackgroundCastration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant to available...
